Results 271 to 280 of about 12,676,118 (406)

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Puckered in pioneer neurons coordinates the motor activity of the Drosophila embryo

, 2023
Karkali K, Vernon S, Baines R, Panayotou G, Martin-Blanco E.   +4 more
europepmc   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Reliability and validity of the Turkish version of the Infant Motor Activity Log in infants with upper extremity functional asymmetry: how often and how well? [PDF]

Turk J Med Sci
Seyhan Biyik K, Özal C, Delioğlu K, Kerem Günel M.   +3 more
europepmc   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

An 8-month adapted motor activity program in a young CMT1A male patient. [PDF]

Front Physiol
Bottoni G, Crisafulli O, Pisegna C, Serra M, Brambilla S, Feletti F, Cremonte G, D'Antona G.   +7 more
europepmc   +1 more source

Features of protein, lipid, carbohydrate and mineral metabolism in descendants of female rats with various motor activities

, 2015
T. V. Gorbach, M. S. Baranova
openalex   +2 more sources

Metal Transporter Zip14 (Slc39a14) Deletion in Mice Increases Manganese Deposition and Produces Neurotoxic Signatures and Diminished Motor Activity [PDF]

, 2017
Tolunay Beker Aydemir, Min‐Hyun Kim, Jin-Hee Kim, Luis M. Colón-Pérez, Guita Banan, Thomas H. Mareci, Marcelo Febo, Robert J. Cousins   +7 more
openalex   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Tubulin CFEOM mutations both inhibit or activate kinesin motor activity. [PDF]

Mol Biol Cell
Luchniak A, Roy PS, Kumar A, Schneider IC, Gelfand VI, Jernigan RL, Gupta ML.   +6 more
europepmc   +1 more source