Results 61 to 70 of about 589,719 (314)

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Motor demand-dependent activation of ipsilateral motor cortex

Journal of Neurophysiology, 2014
The role of ipsilateral primary motor cortex (M1) in hand motor control during complex task performance remains controversial. Bilateral M1 activation is inconsistently observed in functional (f)MRI studies of unilateral hand performance. Two factors limit the interpretation of these data.
Benjamin Hines, Kathleen Pirog Revill, Michael W. Parsons, Linda I. Shuster, Cathrin M. Buetefisch   +4 more
openaire   +3 more sources

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

Assessing Static Balance, Balance Confidence, and Fall Rate in Patients with Heart Failure and Preserved Ejection Fraction: A Comprehensive Analysis

Sensors
Chronic heart failure (CHF) is a complex clinical syndrome, associated with frailty, higher fall rates, and frequent hospitalizations. Heart Failure (HF) and preserved ejection fraction (HFpEF) is defined as a condition where a patient with HF have a ...
Andriana Teloudi, Maria Anifanti, Konstantinos Chatzinikolaou, George Grouios, Vassilia Hatzitaki, Ioanna Chouvarda, Evangelia Kouidi   +6 more
doaj   +1 more source

The Origin of Word-related Motor Activity [PDF]

Cerebral Cortex, 2014
Conceptual processing of verbs consistently recruits the left posterior middle temporal gyrus (lpMTG). The left precentral motor cortex also responds to verbs, with higher activity for action than nonaction verbs. The early timing of this effect has suggested that motor features of words' meaning are accessed directly, bypassing access to conceptual ...
Alvaro Pascual-Leone, Angelika Lingnau, Alfonso Caramazza, Alfonso Caramazza, Liuba Papeo, Sara Agosta, Lorella Battelli   +6 more
openaire   +4 more sources

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Warm-up durations in a hot-dry climate affect thermoregulation, mean power-output and fatigue, but not peak power in specific soccer repeated-sprint ability

BMC Sports Science, Medicine and Rehabilitation, 2020
Background This study addressed the lack of data on the effect of warm-up (WU) duration in hot-dry climate (~ 30 °C; ~ 18% RH), on thermoregulation, muscular power-output, and fatigue after specific soccer repeated-sprint test (RSA).
Mohamed Frikha, Nesrine Chaâri, Noureddine Ben Said, Mohammed Shaab Alibrahim   +3 more
doaj   +1 more source

Comparative Analysis of Motor and Functional Fitness of 6th Grade Boys of an Underfilled School Under Quarantine Conditions

Journal of Learning Theory and Methodology, 2020
The purpose of the study was to determine the dynamics of motor and functional fitness of 6th grade boys of an underfilled school during the school year under quarantine conditions. Materials and methods. The study involved 6th grade boys (n = 6), who
Viktoriia Hladka
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source