Results 81 to 90 of about 652,652 (273)

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Targeting rapid TKI‐induced AXL upregulation overcomes adaptive ERK reactivation and exerts antileukemic effects in FLT3/ITD acute myeloid leukemia

Molecular Oncology, EarlyView.
Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale, Li Li, J. Kyle Bruner, Melody Chou, Bao Nguyen, Jaesung Seo, Ruiqi Zhu, Mark J. Levis, Christine A. Pratilas, Donald Small   +9 more
wiley   +1 more source

The relationship between off-ice testing and on-ice performance in male youth Ice hockey players

Frontiers in Sports and Active Living
IntroductionIce hockey demands a unique blend of physical fitness and skill, necessitating a comprehensive understanding of the factors influencing on-ice performance.
Mark S. Rice, Mark S. Rice, Darren E. R. Warburton, Darren E. R. Warburton, Alejandro Gaytan-Gonzalez, Alejandro Gaytan-Gonzalez, Veronica K. Jamnik, Kai Kaufman, Kai Kaufman, Declan R. D. Warburton, Michael Souster, Shannon S. D. Bredin, Shannon S. D. Bredin   +12 more
doaj   +1 more source

Nível de atividade física em indivíduos com doença arterial periférica: uma revisão sistemática Physical activity level in individuals with peripheral arterial disease: a systematic review

Jornal Vascular Brasileiro, 2012
CONTEXTO: Indivíduos com doença arterial periférica (DAP) apresentam níveis de atividade física diminuídos. Os estudos sobre essa temática apresentam diferenças metodológicas, que variam em relação às características dos indivíduos estudados, aos ...
João Paulo dos Anjos Souza Barbosa, Patrícia Maria Henriques, Mauro Virgílio Gomes de Barros, Nelson Wolosker, Raphael Mendes Ritti-Dias   +4 more
doaj   +1 more source

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

Molecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld, Stefan Kühberger, Ricarda Graf, Christine Beichler, Markus Braun, Nadia Dandachi, Ellen Heitzer, Gerald W. Prager   +7 more
wiley   +1 more source

Tension and chemical efficiency of Myosin-II motors [PDF]

arXiv, 2017
Recent experiments demonstrate that molecular motors from the Myosin II family serve as cross-links inducing active tension in the cytoskeletal network. Here we revise the Brownian ratchet model, previously studied in the context of active transport along polymer tracks, in setups resembling a motor in a polymer network, also taking into account the ...
arxiv  

Integrative systems‐level analysis reveals a contextual crosstalk between hypoxia and global metabolism in human breast tumors

Molecular Oncology, EarlyView.
Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam, Salem Chouaib, Mohammad Askandar Iqbal   +2 more
wiley   +1 more source

Excesso de peso, pressão arterial e atividade física no deslocamento à escola Excess weight, arterial pressure and physical activity in commuting to school: correlations

Arquivos Brasileiros de Cardiologia, 2008
FUNDAMENTO: A prevalência de obesidade e pressão arterial (PA) tem aumentado em crianças e adolescentes, enquanto os domínios da atividade física declinaram. OBJETIVO: Identificar e associar o excesso de peso, de gordura corporal e de PA elevada entre os
Kelly S. Silva, Adair S. Lopes
doaj   +1 more source

Critical role of the motor density and distribution on polar active polymers [PDF]

arXiv
Polar polymer activity is a fundamental mechanism behind a large number of cellular dynamical processes. The number and location of the active sites on the polymer backbone play a central role in their dynamics and conformational properties. Globular conformations for high motor densities change to stretched ones for the more realistic moderate or low ...
arxiv  

The inhibitory effect of stimulation of a thalamic nucleus on neuronal activity in the motor cortex [PDF]

, 1956
Choh‐Luh Li
openalex   +1 more source