Results 151 to 160 of about 18,958,873 (353)

Human arm redundancy: a new approach for the inverse kinematics problem

Royal Society Open Science
The inverse kinematics (IK) problem addresses how both humans and robotic systems coordinate movement to resolve redundancy, as in the case of arm reaching where more degrees of freedom are available at the joint versus hand level.
Avi Barliya, Nili Krausz, Hila Naaman, Enrico Chiovetto, Martin Giese, Tamar Flash   +5 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Robust Control of Induction Motor with H_∞Theory based on Loopshaping [PDF]

, 2011
Hadda Benderradji, Larbi Chrifi‐Alaoui, Sofiane Mahieddine-Mahmoud, Abdessalam Makouf   +3 more
openalex   +1 more source

Disengagement of motor cortex from movement control during long-term learning. [PDF]

, 2019
Motor learning involves reorganization of the primary motor cortex (M1). However, it remains unclear how the involvement of M1 in movement control changes during long-term learning.
Aguilar, Karina, Dahlen, Jeffrey E, Hu, Yvonne Yuling, Hwang, Eun Jung, Komiyama, Takaki, Mitani, Akinori, Mukundan, Madan, Yu, Bin   +7 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Single-Bout Strength: Acute Mental Health Responses to Resistance Training in Active Adults

Sports
Background: Emerging evidence highlights the role of physical exercise as a non-pharmacological intervention for reducing symptoms of anxiety and depression.
Manuel Amore, Adolfo Alfarano, Vincenzo Sorgente, Giulia Panconi, Sara Guarducci, Riccardo Bravi, Diego Minciacchi   +6 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Identification of a cellular node for motor control pathways

, 2014
Ariel J. Levine, Christopher A. Hinckley, Kathryn L. Hilde, Shawn P. Driscoll, Tiffany Poon, Jessica M. Montgomery, Samuel L. Pfaff   +6 more
openalex   +1 more source

DC motor proportional control system for orthotic devices [PDF]

, 1972
Multi-channel proportional control system for operation of dc motors for use with externally-powered orthotic arm braces is described. Components of circuitry and principles of operation are described.
Allen, J. R., Blaise, H. T.
core   +1 more source