Results 91 to 100 of about 486,087 (306)

Intraflagellar Transport: Keeping the Motors Coordinated [PDF]

Current Biology, 2005
Intraflagellar transport is a conserved delivery system that services eukaryotic cilia and flagella. Recent work in the nematode Caenorhabditis elegans has identified proteins required for the functional coordination of intraflagellar transport motors and their cargoes.
openaire   +3 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Dynamical Methods for Evaluating the Time-Dependent Unfolding of Social Coordination in Children with Autism

Frontiers in Integrative Neuroscience, 2013
Children with Autism Spectrum Disorder (ASD) suffer from numerous impairments in social interaction that affect both their mental and bodily coordination with others.
Paula eFitzpatrick, Rachel eDiorio, Michael eRichardson, Richard eSchmidt   +3 more
doaj   +1 more source

Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia [PDF]

, 2016
BACKGROUND: Hyperammonemia induces neuroinflammation and increases GABAergic tone in the cerebellum which contributes to cognitive and motor impairment in hepatic encephalopathy (HE). The link between neuroinflammation and GABAergic tone remains unknown.
Alba Gonzalez-Usano, Ana Agusti, Andrea Cabrera-Pastor, Lucas Taoro-Gonzalez, Marta Llansola, Tiziano Balzano, Vicente Felipo, Vicente Hernandez-Rabaza   +7 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Anthropometry, physical performance, and motor coordination of medallist and non-medallist young fencers [PDF]

, 2018
Background and Study Aim: Fencing is a sport that relies on a complex intra play of numerous performance characteristics. Evaluation of these characteristics is important in the field of talent identification and talent development. Multidimensional test
Lenoir, Matthieu, Mostaert, Mireille, Norjali, Rozilee, Pion, Johan   +3 more
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Influence of facial feedback and mind perception during a cooperative human-robot task in schizophrenia [PDF]

, 2017
This is the author accepted manuscript. The final version is available from Springer Nature via the DOI in this record.Rapid progress in the area of humanoid robots offers tremendous possibilities for investigating and improving social competences in ...
Bardy, B, Billard, A, Bortolon, C, Capdevielle, D, Cohen, L, di Bernardo, M, Khoramshahi, M, Marin, L, Raffard, S, Salesse, RN, Schmidt, R, Slowinski, PM, Tsaneva-Atanasova, K, Zhai, C   +13 more
core   +8 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Brief Report: Visuo-spatial Guidance of Movement during Gesture Imitation and Mirror Drawing in Children with Autism Spectrum Disorders [PDF]

, 2013
Thirteen autistic and 14 typically developing children (controls) imitated hand/arm gestures and performed mirror drawing; both tasks assessed ability to reorganize the relationship between spatial goals and the motor commands needed to acquire them ...
Carson, Audrey Meyer, Eccarius, Petra, Salowitz, Nicole M.G., Scheidt, Robert A., Schohl, Kirsten A., Stevens, Sheryl Jayne, Vaughan van Hecke, Amy   +6 more
core   +1 more source