Results 101 to 110 of about 17,961,119 (345)

Downregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGF(delta/delta) mouse model of amyotrophic lateral sclerosis [PDF]

, 2010
Background: Vascular endothelial growth factor (VEGF) is an endothelial cell mitogen that stimulates vasculogenesis. It has also been shown to act as a neurotrophic factor in vitro and in vivo.
Bender, F.L.P., Brockington, A., Carmeliet, P., Claes, F., Heath, P.R., Holden, H., Kasher, P., Lambrechts, D., Sendtner, M., Shaw, P.J.   +9 more
core   +4 more sources

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Triple-Layer Porous Transport Layers with Ultra-High Porosity for Enhanced Oxygen Transport and Catalyst Utilization in Water Electrolysis

Nano-Micro Letters
Highlights A novel triple-layer Ti-porous transport layer (PTL), fabricated using a practical and scalable tape casting and roll calendering process, enhances catalyst utilization by increasing interfacial contact area and the triple-phase boundary.
Seong Hyun Park, Young Je Park, Seungsoo Jang, Pilyoung Lee, Soobin Yoon, Young-June Park, Chi-Young Jung, Kang Taek Lee   +7 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Development and Implementation - DSIF Development [PDF]

Antenna system instrumentation, phase modulator designs, control systems for transmitter and motor generator, and related DSIF ...

core   +1 more source

Delays in Motor Development in Children with Down Syndrome

Medical Science Monitor, 2015
Background Children with Down syndrome (DS) present with delays in motor development. The reduced size of the cerebrum, brain maturation disorders, and pathophysiological processes lead to motor development delay. The aim of this study was to examine the
R. Malak, A. Kostiukow, A. Krawczyk-Wasielewska, E. Mojs, W. Samborski   +4 more
semanticscholar   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Design and fabrication of an automotive frame model leveraging anisotropic topology optimization and tailored fiber placement

Mechanical Engineering Journal
This paper presents a case study of the design, fabrication, and evaluation of an automotive rear-frame model made of variable axial composites (VAC), using a tailored fiber placement (TFP) technique.
Yoshihiro IWANO, Atsushi WADA, Ryohei TAKAYAMA, Masaaki TANAKA, Yuqing ZHOU, Isao OHASHI, Katsuharu YOSHIKAWA, Atsushi KAWAMOTO, Tsuyoshi NOMURA   +8 more
doaj   +1 more source

Frequency Analysis of Hard Disk Drive Spindle System Supported by Hydrodynamic Bearings

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2007
Herringbone-grooved hydrodynamic bearings are now being applied to hard disk drive (HDD) spindle motors instead of ball bearings for demand for HDDs with larger storage capacities, faster access times, and reduced sizes.
Shohta TOHMA, Toshiaki ISOGAI, Tomoko HIRAYAMA, Takashi MATSUOKA, Katsuhisa YOKOZUKA, Shigeyoshi MORI   +5 more
doaj   +1 more source