Results 251 to 260 of about 2,267,071 (351)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Automatic Movement Recognition for Evaluating the Gross Motor Development of Infants. [PDF]

Children (Basel)
Yang YZ, Tsai JA, Yu YL, Ko MH, Chiou HY, Pai TW, Chen HJ.   +6 more
europepmc   +1 more source

FORMATION OF A SYSTEM FOR ASSESSING THE EFFECTIVENESS OF INNOVATIVE DEVELOPMENT OF LOGISTICS ACTIVITIES OF MOTOR TRANSPORT ENTERPRISES ENGAGED IN FREIGHT TRANSPORTATION IN TERMS OF SUSTAINABLE DEVELOPMENT

Alina Nakaliuzhna
openalex   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Does Judo Training Contribute to the Motor Development of Children and Adolescents? A Systematic Review. [PDF]

J Clin Med
Kowalczyk M, Zgorzalewicz-Stachowiak M, Błach W, Kostrzewa M.   +3 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Examining associations between human milk fatty acids, oligosaccharides, and early infant cognitive, language and motor development in the CHILD cohort study. [PDF]

Front Nutr
Turner SE, Roos LE, Nickel NC, Moraes TJ, Turvey SE, Simons E, Subbarao P, Robertson B, Chikuma J, Goruk S, Field CJ, Bode L, Pei J, Mandhane PJ, Azad MB.   +14 more
europepmc   +1 more source

Comprehensive Evaluation of the Physical Development of Newborns with Different Levels of Spontaneous Motor Activity

, 2019
Е. А. Томилова, Svetlana N. Gordiychuk   +1 more
openalex   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

The needs of parents and their network to influence physical activity and motor development among children 0-to-4-years old: a mixed-methods study protocol. [PDF]

BMC Public Health
Wagijo MR, Altenburg TM, Ledebt A, Bartels F, van der Kaap RK, Bel K, Voorwinden S, van Doodewaard C, van Kann DHH, Gubbels JS, de Moor MHM, ASAS-consortium.   +11 more
europepmc   +1 more source