Results 101 to 110 of about 2,377,140 (335)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
The Influence of Occupational Driver Stress on Work-related Road Safety: An Exploratory Review [PDF]
, 2007 Research has identified a number of stressors that could impact on the occupational driver by increasing stress levels and, for some individuals, causing adverse behaviour and effects, for example, aggressive behaviour, fatigue, inattention/distraction ...
Davey, Jeremy +3 more
core +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Research Synthesis for the California Zero Traffic Fatalities Task Force [PDF]
, 2020 This research synthesis consists of a set of white papers that jointly provide a review of research on the current practicefor setting speed limits and future opportunities to improve roadway safety.
Anthoine, Sonia +7 more
core
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Criminal Liability of Drivers Who Fall Asleep Causing Motor Vehicle Crashes: TLRI Report
Journal of Road Safety, 2011 In October 2010 the Tasmania Law Reform Institute (TLRI) released its Final Report on drivers who fall asleep at the wheel and cause motor vehicle crashes.
R Bradfield, E Newitt
doaj
The American Nightmare: The Ford Edsel Flop and Sputnik Terror [PDF]
, 2016 During the late 1950s, it seemed everyone was pelting Ford Motor Company’s ill-fated Edsel. What was supposed to be the car of the future and an emblem of American prestige had turned into a symbol of America’s sharp decline.
Moran, Nicholas
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source