Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Comparitive study of the influence of harmonic voltage distortion on the efficiency of induction machines versus line start permanent magnet machines [PDF]
, 2012 Induction machines have nearly reached their maximal efficiency. In order to further increase the efficiency the use of permanent magnets in combination with the robust design of the induction machine is being extensively researched. These so-called line
Debruyne, Colin +3 more
core
Model predictive control of a free piston compressor/expander with an integrated linear motor/alternator [PDF]
, 2019 Linear positive displacement machines are becoming increasingly more attractive for applications that are normally known as unconquerable niches of rotary and scroll machines.
De Paepe, Michel +2 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Efficiency at maximum power of interacting molecular machines
, 2012 We investigate the efficiency of systems of molecular motors operating at maximum power. We consider two models of kinesin motors on a microtubule: for both the simplified and the detailed model, we find that the many-body exclusion effect enhances the ...
A. Imparato +3 more
core +1 more source
Endoneural selective stimulating using wire-microelectrode arrays [PDF]
, 1999 In acute experiments eight 5- to 24-wire-microelectrode arrays were inserted into the common peroneal nerve of the rat, to investigate whether the electrodes could selectively stimulate motor units of the extensor digitorum longus (EDL) muscle.
Boom, Herman B.K. +2 more
core +4 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Jumping Mechanography: Reference Centiles in Childhood and Introduction of the Nerve-Muscle Index to Quantify Motor Efficiency. [PDF]
J Clin Med, 2023 Martakis K +6 more
europepmc +1 more source
Using transfer ratio to evaluate EMC design of adjustable speed drive systems [PDF]
, 2006 This paper proposes a way to evaluate the conducted electromagnetic compatibility performance of variable speed drive systems. It is considered that the measured noise level is determined by two factors, the level of the noise source and the conversion ...
Ferreira, B. +4 more
core +1 more source