Results 91 to 100 of about 216,473 (343)

Predictive modeling of TMS-evoked responses: Unraveling instantaneous excitability states

open access: yesNeuroImage
Transcranial magnetic stimulation (TMS) combined with electroencephalography (EEG) and electromyography (EMG) provides a unique window into instantaneous cortical and corticospinal excitability states. We investigated 50 healthy participants to determine
Oskari Ahola   +12 more
doaj   +1 more source

Brain Activity Underlying Muscle Relaxation

open access: yesFrontiers in Physiology, 2019
Fine motor control of not only muscle contraction but also muscle relaxation is required for appropriate movements in both daily life and sports. Movement disorders such as Parkinson’s disease and dystonia are often characterized by deficits of muscle ...
Kouki Kato   +3 more
doaj   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

open access: yesFEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata   +6 more
wiley   +1 more source

The influence of chronic occupational exposure to lead on peripheral nerves conduction

open access: yesMedycyna Pracy
Background The impact of lead on the peripheral nervous system (PNS) remains inadequately explored. Despite the absence of classic lead neuropathy resulting from uncontrolled exposure to high metal doses in workers under biomonitoring, the focus shifts ...
Małgorzata Cisowska   +4 more
doaj   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

open access: yesFEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu   +5 more
wiley   +1 more source

A Novel Latency Estimation Algorithm of Motor Evoked Potential Signals

open access: yesIEEE Access, 2020
Evaluation of motor evoked potential (MEP) signals elicited by transcranial magnetic stimulation (TMS) over the motor cortex provide a measure of cortico-motor excitability at the time of stimulation.
Josko Soda   +4 more
doaj   +1 more source

Evoked potentials in immobilized cats to a combination of clicks with painful electrocutaneous stimuli [PDF]

open access: yes
Averaged evoked potentials in the auditory, somatosensory, and motor cortical zones, as well as in the mesencephalic reticular formation were recorded in acute experiments on nonanesthetized, immobilized cats.
Gilinskiy, M. A., Korsakov, I. A.
core   +1 more source

Facilitatory actions of guanidine on synaptic transmission in mammalian brain slices [PDF]

open access: yes, 1979
Guanidine administration may be beneficial in the treatment of amyotrophic lateral sclerosis and related diseases; however, the actions of guanidine on the mammalian central nervous system have not been investigated.
Galvan, Martin   +2 more
core   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

open access: yesFEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen   +6 more
wiley   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon   +12 more
wiley   +1 more source

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