Results 91 to 100 of about 214,794 (300)

Acid-sensing ion channels 1a (ASIC1a) inhibit neuromuscular transmission in female mice [PDF]

, 2014
Acid-sensing ion channels (ASIC) open in response to extracellular acidosis. ASIC1a, a particular subtype of these channels, has been described to have a postsynaptic distribution in the brain, being involved not only in ischemia and epilepsy, but also ...
Colettis, Natalia Claudia, Gonzalez, Laura Elisabeth, González Inchauspe, Carlota María Fabiola, Lino, Noelia Gisele, Uchitel, Osvaldo Daniel, Urbano Suarez, Francisco Jose, Vattino, Lucas Gabriel, Wemmie, John A., Wunsch, Amanda M.   +8 more
core   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Evoked potentials in immobilized cats to a combination of clicks with painful electrocutaneous stimuli [PDF]

Averaged evoked potentials in the auditory, somatosensory, and motor cortical zones, as well as in the mesencephalic reticular formation were recorded in acute experiments on nonanesthetized, immobilized cats.
Gilinskiy, M. A., Korsakov, I. A.
core   +1 more source

Motor imagery and electrical stimulation reproduce corticospinal excitability at levels similar to voluntary muscle contraction [PDF]

, 2014
BackgroundThe combination of voluntary effort and functional electrical stimulation (ES) appears to have a greater potential to induce plasticity in the motor cortex than either electrical stimulation or voluntary training alone. However, it is not clear
Aoyama Toshiyuki, Hayami Tatsuya, Kaneko Fuminari, Kizuka Tomohiro, 木塚 朝博   +4 more
core   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Magnetic Motor Evoked Potentials in Ponies

Journal of Veterinary Internal Medicine, 1996
Magnetic stimulation of motor pathways was used to effect motor unit action potential recordings from forelimb and hindlimb muscles in unanesthetized ponies. Motor pathway conduction velocities to the forelimb and hindlimb were determined to be 53.8 ± 9.6 m/s‐1and 63.4 ± 8.3 m/s‐1, respectively.
I G, Mayhew, J R, Washbourne
openaire   +2 more sources

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Association of perioperative intravenous lignocaine and intraoperative neuromonitoring in adolescent idiopathic scoliosis surgery: a retrospective study

Perioperative Medicine
Background The use of intravenous (IV) lignocaine as an analgesic adjunct is increasing, but its impact on intraoperative neurophysiological monitoring (IONM) remains unclear.
Siti Nadzrah Yunus, Huey Nee Chong, Zheng-Yii Lee, Rosmalinda Osman, Khean Jin Goh, Chee Kidd Chiu, Chris Yin Wei Chan, Mun Keong Kwan, Mohd Shahnaz Hasan   +8 more
doaj   +1 more source

Prognostic value of cortically induced motor evoked activity by TMS in chronic stroke: caveats from a very revealing single clinical case [PDF]

, 2012
Background: We report the case of a chronic stroke patient (62 months after injury) showing total absence of motor activity evoked by transcranial magnetic stimulation (TMS) of spared regions of the left motor cortex, but near-to-complete recovery of ...
A Catano, A Hübers, AA Qazi, AN Iwaniuk, Antoni Rodríguez-Fornells, Antoni Valero-Cabré, Bahram Mohammadi, BH Dobkin, C Trompetto, Carles Grau, CM Stinear, D Le Bihan, D Waldvogel, DT Wade, EM Wassermann, F Hummel, F Pilato, GW Thickbroom, H Roick, I Loubinoux, J Classen, J Classen, J Doyon, J Hermsdörfer, J Liepert, J Liepert, JA Maldjian, JF Dormont, Jordi Montero, Julià L Amengual, K Oxford Grice, KJ Friston, KR Mills, M Hallett, Misericordia Veciana de las Heras, MW Woolrich, N Dancause, N Sadato, Nils Bodammer, NK Logothetis, Nurja Rojo, P Talelli, Pablo Ripollés, PM Rossini, PM Rossini, PM Rossini, R Traversa, RC Lyle, RS Marshall, S Klöppel, S Schiemanck, SC Cramer, Seán Froudist-Walsh, SM Smith, T Kamida, T Shimizu, TE Conturo, Thomas F Münte, V Delvaux, V Mathiowetz, VM Parker, W Sun, WJ Triggs, ZJ Daskalakis   +63 more
core   +6 more sources

Prediction Model for Etiologic Differentiation of Isolated Vestibular Syndrome in Emergency Settings

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to develop and validate a predictive model for differentiating central from peripheral etiologies in patients with isolated vestibular syndrome (VS). Methods In this multicenter retrospective cohort study, 506 patients with isolated VS from five hospitals were divided into derivation (n = 301) and validation (n = 205)
Guo Wenting, Du Liping, Yang Yi, Hu Jin, Ye Bijun, Wang Jianer, Liu Shuangsi, Guo Shunyuan, Cai Xiaofeng, Wang Huiyuan, Wu Bin, Yu Xiang, Shi Tianming   +12 more
wiley   +1 more source