Results 191 to 200 of about 216,473 (343)

Poly(lactic‐co‐glycolic acid) Nanoparticles for IL‐12 Self‐Amplifying RNA Delivery in Glioblastoma Models

Advanced Functional Materials, EarlyView.
xxxx. ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain cancers, with median survival rarely exceeding 15 months after diagnosis. Interleukin‐12 (IL‐12) is a potent immunostimulatory cytokine capable of reshaping the tumor microenvironment (TME), yet its clinical translation is hindered by systemic toxicity and short half‐life. RNA‐based
Fatima Hameedat, Johan Sebastian Lopez‐Parra, Willem M. H. Hoogaars, Emma Dijkstra, Cynthia Huang, Irafasha C. Casmil, Anna K. Blakney, Peter Olinga, Barbara Rothen‐Rutishauser, Hélder A. Santos, Alke Petri‐Fink, Flávia Sousa   +11 more
wiley   +1 more source

Machine Learning Application of Transcranial Motor-Evoked Potential to Predict Positive Functional Outcomes of Patients. [PDF]

Comput Intell Neurosci, 2022
Jamaludin MR, Lai KW, Chuah JH, Zaki MA, Hasikin K, Abd Razak NA, Dhanalakshmi S, Saw LB, Wu X.   +8 more
europepmc   +1 more source

Clinical Evaluation of the Severity of Spinal Cord Injury with Multimodality Spinal Cord Evoked Potentials -Prognosis and Diagnosis of Injury Level about Pyramidal Tract Disorder with Corticospinal Motor Evoked Potentials（MEP, D-response）-

, 1989
Takashi Tsubokawa, Sadahiro Maejima, Teruyasu Hirayama, Takamitsu Yamamoto, Yoichi Katayama   +4 more
openalex   +2 more sources

Cortical Response to Acute Implantation of the Utah Optrode Array in Macaque Cortex

Advanced Healthcare Materials, EarlyView.
Delivering light deep into the brain over a large volume while causing minimal tissue damage is a major challenge for non‐human primate optogenetics. This study evaluates Utah Optrode Array designs in vivo, revealing how changes in shank geometry, surface texture, and insertion parameters minimize acute damage—offering a path toward high‐precision ...
Adrián Villamarin‐Ortiz, Christopher F. Reiche, Frederick Federer, Andrew M. Clark, John D. Rolston, Cristina Soto‐Sánchez, Eduardo Fernandez, Steve Blair, Alessandra Angelucci   +8 more
wiley   +1 more source

Successful recording of direct cortical motor-evoked potential from a pediatric patient under remimazolam anesthesia: a case report. [PDF]

JA Clin Rep, 2022
Kamata K, Asagi S, Shimoda Y, Kanamori M, Abe N, Sugino S, Tominaga T, Yamauchi M.   +7 more
europepmc   +1 more source

Bone‐Derived dECM Hydrogels Support Tunable Microenvironments for In Vitro Osteogenic Differentiation

Advanced Healthcare Materials, EarlyView.
A tunable methacrylated decellularized bone matrix hydrogel (dECM‐MA) is developed to support 3D culture of human osteoblasts. The hydrogel preserves bone‐specific ECM cues and allows precise control over mechanical properties. This system provides a customizable platform for studying osteogenic differentiation and modeling bone tissue environments for
Minne Dekker, Luke Hipwood, Akhilandeshwari Ravichandran, Dietmar W. Hutmacher, Christoph Meinert, Jacqui McGovern   +5 more
wiley   +1 more source

5-HT₂ antagonism indirectly increases motor unit discharge rate and cervicomedullary motor evoked potential amplitude during submaximal elbow flexions. [PDF]

J Physiol
Henderson TT, Taylor JL, Thorstensen JR, Kavanagh JJ.   +3 more
europepmc   +1 more source

Intraoperative Transcranial Motor-Evoked Potential Monitoring During Head and Neck Surgeries: A Case of Cervical Vagus Nerve Schwannoma With Laryngeal Paralysis. [PDF]

Cureus, 2022
Tanaka A, Uemura H, Takatani T, Kawaguchi M, Hayashi H, Kitahara T.   +5 more
europepmc   +1 more source

Comparative Sensitivity of Intraoperative Motor Evoked Potential Monitoring in Predicting Postoperative Neurologic Deficits: Nondegenerative versus Degenerative Myelopathy [PDF]

, 2015
Allan Clark, Michael Safaee, Dean Chou, Philip R. Weinstein, Annette M. Molinaro, John P. Clark, Praveen V. Mummaneni   +6 more
openalex   +1 more source

Optimization of the Nonclinical Biological Evaluation of Medical Devices Using Toxicologic Pathology Best Practices

Advanced Healthcare Materials, EarlyView.
Nonclinical evaluation of biological responses to implanted medical devices and combination products in animals is required to predict possible outcomes and risks in patients. This paper describes globally accepted pathology “best practices” that 1) effectively address ISO standards and current regulatory guidance for medical device development and 2 ...
Kathleen A. Funk, JoAnn C. L. Schuh, Brad Bolon, Valerie S. Thomas, Jeffrey I. Everitt, Abraham Nyska, Jaime Paulin   +6 more
wiley   +1 more source