Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn +20 more
wiley +1 more source
Impact of various anesthetic regimens on motor-evoked potentials in infants undergoing spinal surgery: A case series. [PDF]
Nakahari H +4 more
europepmc +1 more source
Novel technique of switching TIVA and sevoflurane during epilepsy surgery for combined intraoperative motor evoked potentials monitoring and electrocorticography: an illustrative case report. [PDF]
Mukoyama Y +5 more
europepmc +1 more source
Impact of low-dose sevoflurane with propofol-based anaesthesia on motor-evoked potentials in infants: protocol for a single-centre randomised controlled study. [PDF]
Kojima T +4 more
europepmc +1 more source
The Association of Physiological and Pharmacological Anesthetic Parameters With Motor-Evoked Potentials: A Multivariable Longitudinal Mixed Model Analysis. [PDF]
Dulfer SE +5 more
europepmc +1 more source
Long-Term Motor Deficit in Brain Tumour Surgery With Preserved Intra-Operative Motor-Evoked Potentials. [PDF]
Muscle motor-evoked potentials are commonly monitored during brain tumour surgery in motor areas, as these are assumed to reflect the integrity of descending motor pathways, including the corticospinal tract.
Vincenzo Tramontano +2 more
exaly +2 more sources
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Noninvasive electrical stimulation of the human brain first was attempted in the 1950s. In the early 1980s, the first clinical application method of transcranial electrical stimulation was developed. Investigators in the mid-1980s showed that it was possible to stimulate the nerve and the brain using external magnetic stimulation (transcranial magnetic
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During the last decade, somatosensory evoked potentials (SSEP) have become established as a practical method for monitoring the spinal cord during various surgical procedures where there is a risk of paraplegia, e.g., scoliosis surgery, thoracic aortic surgery, and neurosurgical procedures upon the spinal cord. However, it has also become apparent that
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A complication resulting from surgery for spinal deformity and certain types of aortic aneurysms is a loss of spinal cord function. In order to detect the intraoperative occurrence of this event, techniques, that monitor spinal cord function are administered.
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