Results 91 to 100 of about 13,124,622 (407)
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Acute responses of circulating microRNAs to low-volume sprint interval cycling
Frontiers in Physiology, 2015 Low-volume high-intensity interval training is an efficient and practical method of inducing physiological responses in various tissues to develop physical fitness and may also change the expression of circulating microRNAs (miRNAs).
Shu Fang eCui +10 more
doaj +1 more source
Frontiers in Neurology, 2022 Introduction: Proprioceptive impairment is a common symptom after stroke. Clarifying how proprioception correlates with motor function after stroke may be helpful in optimizing proprioception-augmented movement training.
Yifan Yu +4 more
doaj +1 more source
Journal of Orthopaedic Science, 2015 BackgroundMotor dysfunction is a major reason why the elderly lose their independence in their daily lives. The concept of locomotive syndrome has been proposed to describe the risk of mobility dependence caused by various locomotive organ disorders. The
T. Ogata +7 more
semanticscholar +1 more source
FEBS Letters, EarlyView.The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp +5 more
wiley +1 more source
Journal of Stem Cells and Regenerative Medicine, 2015 A hypoxic environment is thought to be important for the maintenance of stemness and suppressing cell senescence, in stem cells. Therefore, a hypoxic condition is induced during cell expansion and/or induction of intended differentiation.
Ito A +8 more
doaj
Neuronal Lamin regulates motor circuit integrity and controls motor function and lifespan
Cell Stress, 2018 Neuronal aging involves a progressive decline in cognitive abilities and loss of motor function. Mutations in human Lamin genes (LMNA, LMNB1, LMNB2) lead to a wide-range of diseases including muscular dystrophy, peripheral neuropathy and progeria.
Lisa J. Oyston +6 more
doaj +1 more source
BMC Medical Research Methodology, 2006 BackgroundIn order to better understand the similarities and differences in the motor behaviour of different groups of patients, their scores on the Motor Examination section of the Unified Parkinson's Disease Rating Scale (UPDRS) were analysed ...
P. Kroonenberg +5 more
semanticscholar +1 more source
FEBS Letters, EarlyView.UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg +2 more
wiley +1 more source
Role of the Contralesional Hemisphere in Post-Stroke Recovery of Upper Extremity Motor Function
Frontiers in Neurology, 2015 Identification of optimal treatment strategies to improve recovery is limited by the incomplete understanding of the neurobiological principles of recovery.
C. Buetefisch
semanticscholar +1 more source