Results 191 to 200 of about 13,151,197 (407)
Landscape of BRAF transcript variants in human cancer
Molecular Oncology, EarlyView.We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda +5 more
wiley +1 more source
Beneficial effect of pramipexole for motor function and depression in Parkinson’s disease
Neuropsychiatric Disease and Treatment, 2009 Osamu Kano1,2, Ken Ikeda2, Tetsuhito Kiyozuka2, Konosuke Iwamoto2, Hirono Ito2, Yuji Kawase2, Ryuta Sato2, Toshiki Fujioka2, Yo Araki2, Shigeji Baba2, Yasuo Iwasaki21Department of Neurology, Methodist Neurological Institute, Houston, TX, USA; 2Department
Osamu Kano +5 more
doaj
Molecular Oncology, EarlyView.This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh +8 more
wiley +1 more source
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Secretomotor function of the dorsal motor nucleus of the vagus
, 1969 Frederick W. L. Kerr, R. M. Preshaw
openalex +1 more source
Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Molecular Oncology, EarlyView.Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte +10 more
wiley +1 more source
Cesarean Section before the Onset of Labor and Subsequent Motor Function in Infants with Meningomyelocele Diagnosed Antenatally [PDF]
, 1991 David A. Luthy +6 more
openalex +1 more source