Results 41 to 50 of about 13,568,227 (260)

In vivo genome editing improves motor function and extends survival in a mouse model of ALS

Science Advances, 2017
CRISPR-Cas9–mediated genome editing can be used to treat ALS in an animal model of the disease. Amyotrophic lateral sclerosis (ALS) is a fatal and incurable neurodegenerative disease characterized by the progressive loss of motor neurons in the spinal ...
T. Gaj, David S. Ojala, Freja K. Ekman, L. Byrne, Prajit Limsirichai, D. Schaffer   +5 more
semanticscholar   +1 more source

Desensitization of the Cough Reflex Induced by Corticosteroids in Ovalbumin-Sensitized Rabbits During Artificial Limb Exercise

Frontiers in Physiology, 2020
IntroductionCough is a major symptom frequently experienced during exercise, mainly in asthmatic patients. Inhaled glucocorticoids represent the keystone treatment in the management of asthma, but little is known about interactions between cough and ...
Simon Valentin, Simon Valentin, Bruno Chenuel, Bruno Chenuel, Silvia Demoulin-Alexikova, Bruno Demoulin, Delphine Gérard, Laurent Foucaud, Mathias Poussel, Mathias Poussel   +9 more
doaj   +1 more source

Defective axonal transport in motor neuron disease [PDF]

, 2007
Several recent studies have highlighted the role of axonal transport in the pathogenesis of motor neuron diseases. Mutations in genes that control microtubule regulation and dynamics have been shown to cause motor neuron degeneration in mice and in a ...
Baas, Blair, Boillee, Bommel, Borchelt, Bowling, Brown, Bruijn, Burger, Cao, Cleveland, Cleveland, Duchen, Escurat, Evans, Fichera, Fliegner, Gaudette, Goldstein, Hadano, Hafezparast, Hazan, Hirokawa, Hirokawa, Hirokawa, Jablonka, Joshi, Kanai, Kaplan, Kieran, King, Kong, LaMonte, Levy, Ligon, Liu, Lo Giudice, Lu, Martin, Miki, Miki, Mitsumoto, Mitsumoto, Muglia, Munch, Nicholson, Nishimura, Okabe, Otomo, Parkinson, Parysek, Pasinelli, Patel, Proukakis, Puls, Puls, Quenneville, Rao, Reid, Reid, Reid, Rosen, Ross, Rowland, Sanderson, Schmitt-John, Shaw, Shibata, Siegel, Song, Teuchert, Troy, Vallee, Weber, Williamson, Wood, Xia, Zhao   +77 more
core   +1 more source

Screening of the transcriptional regulatory regions of vascular endothelial growth factor receptor 2 (VEGFR2) in amyotrophic lateral sclerosis [PDF]

, 2007
Background Vascular endothelial growth factor (VEGF) has neurotrophic activity which is mediated by its main agonist receptor, VEGFR2. Dysregulation of VEGF causes motor neurone degeneration in a mouse model of amyotrophic lateral sclerosis (ALS), and
Brockington, A., Hartley, J., Nixon, H., Shaw, P.J., Wokke, B.   +4 more
core   +3 more sources

Association of skeletal muscle strength and cardiorespiratory fitness with bone mineral density: a cross-sectional study

Frontiers in Public Health
BackgroundThe high prevalence and increasing severity of osteoporosis have elevated it to a significant global public-health concern, imposing a substantial economic burden.
Beibei Wei, Zelong Miao, Xinge Yang, Xinge Yang, Shuning Chen, Xueying Guo, Jixiang Wang, Xu Huang, Hanping Zhang, Xuan Wang, Bin Jia   +10 more
doaj   +1 more source

The Relationship Between Big Five and Self-Control in Boxers: A Mediating Model

Frontiers in Psychology, 2019
Self-control seems to be the core element for achieving optimal competitive performance, and be of great importance to well-being and healthy development of humans. According to the literature, there exist some correlations between personality traits and
Guodong Zhang, Xin Chen, Luxia Xiao, Yun Li, Bing Li, Zi Yan, Liya Guo, Detlef H. Rost, Detlef H. Rost   +8 more
doaj   +1 more source

Association Between Changes in Muscle Strength and Risk of Depressive Symptoms Among Chinese Female College Students: A Prospective Cohort Study

Frontiers in Public Health, 2021
Muscle strength can be a predictor of depressive symptoms among the elderly. We conducted a prospective study aiming to examine the association between change of handgrip strength and the incidence risk of depressive symptoms among Chinese female college
Jianhua Cao, Fang Zhao, Zhongyu Ren
doaj   +1 more source

Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling. [PDF]

, 2010
Topographic neuronal maps arise as a consequence of axon trajectory choice correlated with the localisation of neuronal soma, but the identity of the pathways coordinating these processes is unknown.
Kania, Artur, Kao, Tzu-Jen, Klar, Avihu, Laufer, Ed, Novitch, Bennett G, Okamoto, Hitoshi, Palmesino, Elena, Rousso, David L, Uemura, Osamu   +8 more
core   +4 more sources

Mirror therapy for motor function of the upper extremity in patients with stroke: A meta-analysis.

Journal of Rehabilitation Medicine, 2018
OBJECTIVE To evaluate the mean treatment effect of mirror therapy on motor function of the upper extremity in patients with stroke. DATA SOURCES Electronic databases, including the Cochrane Library, PubMed, MEDLINE, Embase and CNKSystematic, were ...
Wen Zeng, Yonghong Guo, Guofeng Wu, Xueyan Liu, Q. Fang   +4 more
semanticscholar   +1 more source

Structure and Function of Stator Units of the Bacterial Flagellar Motor

Cell, 2020
Many bacteria use the flagellum for locomotion and chemotaxis. Its bi-directional rotation is driven by the membrane-embedded motor, which uses energy from the transmembrane ion gradient to generate torque at the interface between stator units and rotor.
M. Santiveri, A. Roa-Eguiara, Caroline Kühne, N. Wadhwa, H. Berg, M. Erhardt, N. Taylor   +6 more
semanticscholar   +1 more source