Individual heat map assessments demonstrate vestronidase alfa treatment response in a highly heterogeneous mucopolysaccharidosis VII study population. [PDF]
, 2019 Mucopolysaccharidosis (MPS) VII is an ultra-rare, progressively debilitating, life-threatening lysosomal disease caused by deficiency of the enzyme, β-glucuronidase. Vestronidase alfa is an approved enzyme replacement therapy for MPS VII. UX003-CL301 was
Bauer, Mislen +7 more
core +1 more source
Journal of Stem Cells and Regenerative Medicine, 2015 A hypoxic environment is thought to be important for the maintenance of stemness and suppressing cell senescence, in stem cells. Therefore, a hypoxic condition is induced during cell expansion and/or induction of intended differentiation.
Ito A +8 more
doaj
Neuronal Lamin regulates motor circuit integrity and controls motor function and lifespan
Cell Stress, 2018 Neuronal aging involves a progressive decline in cognitive abilities and loss of motor function. Mutations in human Lamin genes (LMNA, LMNB1, LMNB2) lead to a wide-range of diseases including muscular dystrophy, peripheral neuropathy and progeria.
Lisa J. Oyston +6 more
doaj +1 more source
Motor proteins traffic regulation by supply-demand balance of resources
, 2014 In cells and in vitro assays the number of motor proteins involved in biological transport processes is far from being unlimited. The cytoskeletal binding sites are in contact with the same finite reservoir of motors (either the cytosol or the flow ...
Ciandrini, Luca +4 more
core +3 more sources
Schizophrenia Spectrum Disorders: Linking Motor and Process Skills, Sensory Patterns, and Psychiatric Symptoms [PDF]
, 2020 Background: Consistent evidence suggests sensory abnormalities and skill deficits in people with Schizophrenia Spectrum Disorder (SSD). Further exploration of their sensory patterns and performance skills is warranted to promote community participation ...
Falk-Kessler, Janet, Halperin, Lola
core +3 more sources
Association of Glycative Stress With Motor and Muscle Function [PDF]
, 2022 Tatsuro Egawa, Tatsuya Hayashi
openalex +1 more source
Hybrid brain-computer interface and functional electrical stimulation for sensorimotor training in participants with tetraplegia: a proof-of-concept study [PDF]
, 2015 Background and Purpose: Impaired hand function decreases quality of life in persons with tetraplegia. We tested functional electrical stimulation (FES) controlled by a hybrid brain-computer interface (BCI) for improving hand function in participants with
Aguilar +36 more
core +1 more source
The effectiveness of proprioceptive training for improving motor function: a systematic review
Frontiers in Human Neuroscience, 2015 Objective: Numerous reports advocate that training of the proprioceptive sense is a viable behavioral therapy for improving impaired motor function. However, there is little agreement of what constitutes proprioceptive training and how effective it is ...
Joshua Aman +3 more
semanticscholar +1 more source
Motor Output Variability Impairs Driving Ability in Older Adults [PDF]
, 2016 Background: The functional declines with aging relate to deficits in motor control and strength. In this study, we determine whether older adults exhibit impaired driving as a consequence of declines in motor control or strength. Methods: Young and older
Christou, Evangelos A. +4 more
core +2 more sources
The effectiveness of virtual reality cycling exercise towards the motoric and cardiorespiratory functions of post-stroke patients [PDF]
, 2023 I Putu Dody Lesmana +4 more
openalex +1 more source