Results 41 to 50 of about 29,894 (261)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Estimating motor competence through motor games

, 2019
El principal objetivo del trabajo es abordar la estimación de la competencia motriz de las niñas y niños desde la espontaneidad del juego motor. Se selecionaron 112 individuos de grupos mixtos (M = 14,2; SD = 2,2) para la práctica de dos juegos motores.
Pic, Miguel, Lavega i Burgués, Pere
openaire   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Compilation of Motor Games according to sports games

, 2020
Resumen: Introducción: Definimos Juego Motor como: Juego vinculado a un objetivo motor (o con movimiento) ya que para conseguir el/los objetivos el/los jugadores lo consiguen a través del movimiento. Las recopilaciones de Juegos Motores son parte necesaria de la que partir para analizar los Juegos Motores.
Cueto Martín, María Belén, Fernández Revelles, Andrés Bernardo   +1 more
openaire   +2 more sources

Motors and Impossible Firing Patterns in the Parallel Chip-Firing Game [PDF]

SIAM Journal on Discrete Mathematics, 2015
19 pages; added higher-level explanation of main theorem's proof, typo ...
Tian-Yi Jiang, Ziv Scully, Yan X. Zhang
openaire   +5 more sources

Intelligent Tutoring Systems for Adult Learning in STEM Disciplines

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley   +1 more source

Effectiveness of Virtual-Assisted Motor Games for Improving Balance in Children with Special Educational Needs

Romanian Journal of Physical Therapy
Introduction: Children with special educational needs (SEN) often present with balance and mobility deficits that limit their independence. Virtual reality and interactive video games have shown potential as engaging tools in paediatric rehabilitation.
Nicolae Lucian MOLDOVAN, Evelyn Karolina MOLDOVAN, Anca-Cristina POP, Dana Ioana CRISTEA, Ioan-Cosmin BOCA   +4 more
doaj   +1 more source

Compilation of Motor Games according to motor development

, 2020
Resumen: Introducción: Definimos Juego Motor como: Juego vinculado a un objetivo motor (o con movimiento) ya que para conseguir el/los objetivos el/los jugadores lo consiguen a través del movimiento. Las recopilaciones de Juegos Motores son parte necesaria de la que partir para analizar los Juegos Motores.
Fernández Revelles, Andrés Bernardo, Cueto Martín, María Belén   +1 more
openaire   +1 more source

Dynamic Difficulty Adaptation in Serious Games for Motor Rehabilitation [PDF]

, 2014
In the last few years, a growing interest has been devoted to improve rehabilitation strategies by including serious games in the therapy process. Adaptive serious games seek to provide the patients with an individualized rehabilitation environment that meets their training needs.
Hocine, Nadia, Gouaich, Abdelkader, Cerri, Stefano A.   +2 more
openaire   +1 more source