Results 41 to 50 of about 1,638,173 (256)

Structure of the human TIP60 complex

Nature Communications
Mammalian TIP60 is a multi-functional enzyme with histone acetylation and histone dimer exchange activities. It plays roles in diverse cellular processes including transcription, DNA repair, cell cycle control, and embryonic development.
Ke Chen, Li Wang, Zishuo Yu, Jiali Yu, Yulei Ren, Qianmin Wang, Yanhui Xu   +6 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Protection and Control Module of Motor of Shearer Based on TMS320F2812

Gong-kuang zidonghua, 2011
In order to make on-line monitoring and earlier fault diagnosis of motor of shearer effectively, a protection and control module of motor of shearer based on TMS320F2812 was designed, and designs of hardware circuit and software of the module were ...
ZHANG Fu-jia
doaj  

Motor modules are largely unaffected by pathological walking biomechanics: a simulation study

Journal of NeuroEngineering and Rehabilitation
Background Motor module (a.k.a. muscle synergy) analysis has frequently been used to provide insight into changes in muscle coordination associated with declines in walking performance, to evaluate the effect of different rehabilitation interventions ...
Mohammad Rahimi Goloujeh, Jessica L. Allen   +1 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Design of an Intelligent Control System of Mine-used Valve

Gong-kuang zidonghua, 2012
In view of problem that control requirements of mine-used valve controller become more and more complex, the paper proposed a design scheme of intelligent control system of mine-used valve based on M0516LAN microcontroller. The system is composed of main
LIU Yan, MA Wei-hua
doaj  

Improving Performance of Squirrel Cage Induction Motor Used in Submersible Pumps

Electrical Engineering and Energy
This study examines the design of a three-phase induction motor used in submersible pumps. The motor considered is a 380V, 50Hz, 75Hp, 2-pole, 8" three-phase induction motor. The targeted induction motor performance is high efficiency at the rated load.
Mümtaz Mutluer
doaj   +1 more source

Cerebellar connectome alterations and associated genetic signatures in multiple sclerosis and neuromyelitis optica spectrum disorder

Journal of Translational Medicine, 2023
Background The cerebellum plays key roles in the pathology of multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD), but the way in which these conditions affect how the cerebellum communicates with the rest of the brain (its ...
Yuping Yang, Junle Li, Ting Li, Zhen Li, Zhizheng Zhuo, Xuemei Han, Yunyun Duan, Guanmei Cao, Fenglian Zheng, Decai Tian, Xinli Wang, Xinghu Zhang, Kuncheng Li, Fuqing Zhou, Muhua Huang, Yuxin Li, Haiqing Li, Yongmei Li, Chun Zeng, Ningnannan Zhang, Jie Sun, Chunshui Yu, Fudong Shi, Umer Asgher, Nils Muhlert, Yaou Liu, Jinhui Wang   +26 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source