Results 361 to 370 of about 2,351,931 (407)

Motor neurone disease

2018
Motor neurone disease (MND) patients exhibit poor gait, balance, and postural control, all of which significantly increases their risk of falling. Falls are frequent in the MND population, and are associated with an increased burden of disease. The complex interplay of both motor and extramotor manifestations in this disease contributes to the ...
William Huynh, Matthew C. Kiernan, José Manuel Matamala, Margaret C. Zoing, Thanuja Dharmadasa   +4 more
openaire   +2 more sources

Of mice, men and motor neurons

Trends in Molecular Medicine, 2001
The use of mouse models has been of particular importance in studying the pathogenesis of amyotrophic lateral sclerosis. Here, we describe both transgenic and classical mutants for which the genetic lesion is known. We draw attention, wherever possible, to pathological factors common to multiple models.
Catherine M. Abbott, Helen J Newbery
openaire   +5 more sources

Motor neurone disease

Nursing Standard, 2016
Essential facts Motor neurone disease describes a group of related diseases, affecting the neurones in the brain and spinal cord. Progressive, incurable and life-limiting, MND is rare, with about 1,100 people developing it each year in the UK and up to 5,000 people affected at any one time.
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Upper Motor Neuron

de Lahunta's Veterinary Neuroanatomy and Clinical Neurology, 2021
A. de Lahunta, E. Glass, Marc Kent
semanticscholar   +1 more source

Motor neurons rely on motor proteins

Trends in Cell Biology, 2004
The importance of active axonal transport to the neuron has been highlighted by the recent discoveries that mutations in microtubule motor proteins result in neurodegenerative diseases. Mutations affecting microtubule motor function have been shown to cause hereditary forms of Charcot-Marie-Tooth disease (type 2A), hereditary spastic paraplegia and ...
openaire   +3 more sources

Motor Neuron Diseases

2013
Motor neuron diseases (MNDs) represent a group of neurological diseases characterized by progressive deterioration of the motor neurons in the brain, brain stem, and spinal cord, leading to muscle weakness and wasting. Genetic MND may be caused by mutations in genes that are widely expressed.
Quijano-Roy, S., Avila-Smirnow, D., Carlier, R.Y., Wattjes, M.P., Fischer, D.   +4 more
openaire   +3 more sources

Motor neuron disease

2018
Motor neuron disease (MND) is characterized by progressive muscular weakness due to simultaneous degeneration of lower and upper motor neurons (L/UMNs). Involvement of LMNs, arising from the anterior horns of the spinal cord and brainstem, leads to secondary wasting as a result of muscle denervation.
openaire   +1 more source

Autophagy in motor neuron diseases

2020
Motor neuron diseases (MNDs) are a wide group of neurodegenerative disorders characterized by the degeneration of a specific neuronal type located in the central nervous system, the motor neuron (MN). There are two main types of MNs, spinal and cortical MNs and depending on the type of MND, one or both types are affected.
openaire   +3 more sources

Astrocytes in Motor Neuron Diseases

2019
Motor neuron disorders are highly debilitating and mostly fatal conditions for which only limited therapeutic options are available. To overcome this limitation and develop more effective therapeutic strategies, it is critical to discover the pathogenic mechanisms that trigger and sustain motor neuron degeneration with the greatest accuracy and detail.
Valori, Chiara F., Guidotti, Giulia, Brambilla, Liliana, Rossi, Daniela   +3 more
openaire   +3 more sources

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation.

Science, 1994
M. Gurney, Haifeng Eishingdrelo (Pu), A. Y. Chiu, M. D. Dal Canto, C. Y. Polchow, D. D. Alexander, J. Caliendo, A. Hentati, Y. Kwon, H. Deng   +9 more
semanticscholar   +1 more source