Results 291 to 300 of about 3,875,303 (358)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

The Associations of SUNRISE Product-Oriented Gross Motor Skills With Process-Oriented TGMD-3. [PDF]

J Mot Learn Dev
Spring KE, Staiano AE, Brandon D, Okely AD, Webster EK.   +4 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Assessing fundamental motor skills proficiency in school-based sports physical education programs: implications for talent development. [PDF]

Front Sports Act Living
Makaruk H, Webster EK, Porter J, Makaruk B, Bodasińska A, Zieliński J, Tomaszewski P, Nogal M, Starzak M, Śliwa M, Banaś M, Biegajło M, Chaliburda A, Suchecki B, Molik B, Sadowski J.   +15 more
europepmc   +1 more source

Research Paper: The Relationship Between Fine Motor Skills and Social Development and Maturation

, 2017
Leila Dehghan, Navid Mirzakhani, Mehdi Rezaee, Mehdi Tabatabaee   +3 more
openalex   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Exploring the Efficacy of the Occupational Therapy-Fundamental Motor Skills Training (OT-FMST) Protocol on Functional Performance in Children With Autism Spectrum Disorder. [PDF]

Cureus
Jain JG, Sharma RK, Bhardwaj S, Irem S, Dwivedi A.   +4 more
europepmc   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Fine Motor Skills, Executive Function, and School Readiness in Preschoolers with Externalizing Behavior Problems. [PDF]

Behav Sci (Basel)
Karimi A, Poznanski B, Hart KC, Nelson EL.   +3 more
europepmc   +1 more source