Results 91 to 100 of about 1,099,877 (344)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

A computational theory of motor learning [PDF]

, 1987
In this paper we present a computational theory of human motor performance and learning. The theory is implemented as a running AI system called MAGGIE. Given a description of a desired movement as input, the system generates simulated motor behavior as ...
Iba, Wayne, Langley, Pat
core  

Event Perception: Motor Theory vs. Direct Perception Theory

Journal of Psychology and Behavioral Science, 2014
People observe lots of events around the environment and we can easily recognize the nature of an event from the resulting optic flow. The questions are how do people recognize events and what is the information in the optic flow that enables observers to recognize events.
openaire   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Role of beta-band resting-state functional connectivity as a predictor of motor learning ability

NeuroImage, 2020
It has been suggested that resting-state functional connectivity (rs-FC) between the primary motor area (M1) region of the brain and other brain regions may be a predictor of motor learning, although this suggestion is still controversial.
Hisato Sugata, Kazuhiro Yagi, Shogo Yazawa, Yasunori Nagase, Kazuhito Tsuruta, Takashi Ikeda, Ippei Nojima, Masayuki Hara, Kojiro Matsushita, Kenji Kawakami, Keisuke Kawakami   +10 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Chance, long tails, and inference: a non-Gaussian, Bayesian theory of vocal learning in songbirds

, 2017
Traditional theories of sensorimotor learning posit that animals use sensory error signals to find the optimal motor command in the face of Gaussian sensory and motor noise.
Hofmann, David, Nemenman, Ilya, Pinkoviezky, Itai, Sober, Samuel J., Zhou, Baohua   +4 more
core  

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Cooperative Cargo Transport by Several Molecular Motors

, 2005
The transport of cargo particles which are pulled by several molecular motors in a cooperative manner is studied theoretically. The transport properties depend primarily on the maximal number, $N$, of motor molecules that may pull simultaneously on the ...
Ashkin, Bell, Block, B  hm, Erdmann, Goldstein, Hill, Kuznetsov, Lipowsky, Miller, R. Lipowsky, S. Klumpp, Schnitzer, Seitz, Shah, Svoboda, Trinczek, Vale, Visscher, Wang   +19 more
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source