Results 191 to 200 of about 64,139 (265)

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Police Pursuit Fatalities in the US, 2009 to 2023.

JAMA Netw Open
Hendrix A, Martin T, Gazzetta J, Nunez J.   +3 more
europepmc   +1 more source

GS-YOLO: A lightweight high-accuracy model for small target detection in drone aerial images. [PDF]

PLoS One
Jin X, Zhu X, Kang D, Shen W, Zhao Y, Li X, Yuan B, Zhao Y.   +7 more
europepmc   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

An Ultralight Launch-and-Recovery System for Tethered Micro Unmanned Aerial Vehicles on Small Unmanned Ground Vehicles. [PDF]

Sensors (Basel)
Liu Y, Shen Z, Xu J, Chen S, Zhang B, Xu S.   +5 more
europepmc   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

New energy vehicle fault identification based on improved activation functions and parameter-free attention mechanisms. [PDF]

Sci Rep
Yan J, Wu H, Dai W.
europepmc   +1 more source

Development of the DADSS* Breath Alcohol Sensor System for Automobiles: Technical Design and Human Participant Testing. [PDF]

Sensors (Basel)
Pirooz K, Allen T, Spicer R, Kalmar S, Liu J, McNeil J, Vitaliano G, Lukas SE.   +7 more
europepmc   +1 more source