Results 51 to 60 of about 3,323 (268)
FEBS Letters, EarlyView.Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley +1 more source
Development of a Segregated Compressible Flow Solver for Turbomachinery Simulations
Journal of Applied Fluid Mechanics, 2014 A steady multiple reference frame segregated compressible solver and an unsteady sliding mesh one are developed using OpenFOAM® to simulate turbomachinery.
Jesús Benajes +3 more
doaj
Transportation Engineering, 2020 To achieve the targets of extreme low emissions values for the transport sector, several technologies emerged in the last few years. In this sense, advanced combustion modes as the dual-fuel low temperature combustion showed great advantages in terms of ...
Jesús Benajes +3 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Computational Methodology for Knocking Combustion Analysis in Compression-Ignited Advanced Concepts
Applied Sciences, 2018 In the present work, a numerical methodology based on three-dimensional (3D) computational fluid dynamics (CFD) was developed to predict knock in a 2-Stroke engine operating with gasoline Partially Premixed Combustion (PPC) concept. Single-cycle Unsteady
José Ramón Serrano +3 more
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
A modelling tool for engine and exhaust aftertreatment performance analysis in altitude operation
Results in Engineering, 2019 New regulation standards on engine pollutant emissions are widening the engine operating conditions subjected to type approval tests as a way to prevent from the gap between regulated and real-driving emissions.
J.R. Serrano +3 more
doaj +1 more source
Impact of Exhaust Gas Recirculation on Gaseous Emissions of Turbocharged Spark-Ignition Engines
Applied Sciences, 2020 Exhaust gas recirculation is one of the technologies that can be used to improve the efficiency of spark-ignition engines. However, apart from fuel consumption reduction, this technology has a significant impact on exhaust gaseous emissions, inducing a ...
Pedro Piqueras +3 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source