Results 41 to 50 of about 2,121 (215)

Mechanical states of a motor protein in the spindle

Current Biology
Motor proteins perform essential roles in spindle assembly and division, but little is known about the forces that motors produce in spindles. Here, we report new tension sensors designed to measure loads across a kinesin-14 motor protein that both slides and crosslinks microtubules in spindles.
Kevin K. Do, Ian Greear, Umika S. Paul, Neil Billington, Zimiao Meng, Matthew Y. Wang, Rong Liu, Brenton D. Hoffman, Sharyn A. Endow   +8 more
openaire   +3 more sources

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source

Energy Optimization for Motorized Spindle System of Machine Tools under Minimum Thermal Effects and Maximum Productivity Constraints

Energies, 2020
Motorized spindle system is one of the crucial components affecting the machine tools energy performance. Many previous studies have examined its energy optimization problems, however, most such studies focused mainly on parameters optimization to ...
Benjie Li, Hualin Zheng, Xiao Yang, Liang Guo, Binglin Li   +4 more
doaj   +1 more source

Microtubule motors in eukaryotic spindle assembly and maintenance

Seminars in Cell & Developmental Biology, 2010
The main function of the mitotic spindle is to accurately segregate replicated chromosomes during cell division. This dynamic, microtubule-based structure is assembled by a dividing cell and facilitates the orchestrated movement of chromosomes that is the hallmark of mitosis. Steady-state spindle size and morphology are relatively constant for cells of
Jesse C, Gatlin, Kerry, Bloom
openaire   +3 more sources

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source

A Computational Strategy for Identifying Self‐Assembling Food‐Derived Molecules for Antiparasitic Nanotherapy

Advanced Science, EarlyView.
An integrated computational screening strategy identified ursolic acid (UA) and 18β‐glycyrrhetinic acid (18βGA) as a self‐assembling food‐derived molecular pair. The resulting carrier‐free nanoparticles (UA‐18βGA) showed synergistic antiparasitic activity, reduced combined toxicity, and host‐protective anti‐inflammatory effects in zebrafish and murine ...
Shenye Qu, Ting Wang, Jietao Liu, Jiacheng Qin, Bin Yang, Yihang Liu, Pengfei Li, Gaoxue Wang, Fei Ling   +8 more
wiley   +1 more source

Thermal error prediction model of high-speed motorized spindle based on DELM network optimized by weighted mean of vectors algorithm

Case Studies in Thermal Engineering, 2023
The thermal error compensation process of high-speed motorized spindle needs to establish an effective prediction model. In this study, firstly, the thermal characteristics of a motorized spindle are tested, and the data at different speeds are obtained.
Ye Dai, Jian Pang, XuKun Rui, WeiWei Li, QingHai Wang, ShiKun Li   +5 more
doaj   +1 more source

Spatiotemporal Control of Formation of Dynamic Protein Fiber Assemblies via Photophysical Effects of a Focused Laser Beam

Advanced Science, EarlyView.
Tightly focused laser irradiation can accumulate tubulin proteins at/around the laser focus, which leads to the formation of highly ordered microtubule assemblies. The assemblies can exhibit various dynamic behaviors such as radial motion, bundling, and flagella‐like rotation with motor protein and chemical energy, highlighting as a unique tool for ...
Hiroshi Y. Yoshikawa, Ren Shirata, Takuya Takeshige, Riki Yoshida, Fumika Kiryu, Kei Takano, Shuma Matsumoto, Reiji Kawanami, Natsumi Sawada, Chi‐Shiun Wu, Yang‐Hsin Shih, Hiromasa Niinomi, Takahisa Matsuzaki, Seiichiro Nakabayashi, Tomoaki Matsuura, Teruki Sugiyama, Ryuzo Kawamura   +16 more
wiley   +1 more source

THERMAL CHARACTERISTIC ANALYSIS METHOD OF MOTORIZED SPINDLE BASED ON THERMAL LOAD OPTIMIZATION CORRECTION

Jixie qiangdu, 2020
For the inaccuracy of empirical heat loads for spindle thermal simulations,a thermal simulation analysis method onto motorized spindle unit is proposed.Firstly,the fluid-solid-heat coupling simulation model of the motorized spindle unit is established by
MENG LingCong, LI ChenTao, YU Bing, LIU Teng, ZHANG JianJun   +4 more
doaj  

“Membrane‐Guided” Repair Strategy: Precision Delivery of GGT1 Degrader for Targeted Repair and Regeneration of Spinal Cord Neurons

Advanced Science, EarlyView.
This study confirms that GGT1 is a key driver of neuronal ferroptosis following spinal cord injury. We developed NSCm@EA, a biomimetic delivery system coated with neural stem cell membranes, for precise delivery of enocyanin to injured neurons. By combining targeted delivery with ubiquitination degradation mechanisms, this system promotes MGRN1 ...
Tao Yang, Lei Ye, Peigen Xie, Tao Song, Jian Chen, Heng Zhao, Zhengshan Liu, Xi Chen, Jianing Ding, Xintian Ding, Ao Shao, Miaomiao Wu, Fengdong Zhao, Siyue Tao, Tao You   +14 more
wiley   +1 more source