Results 41 to 50 of about 5,558 (259)

Nonviral Gold Nanoparticle‐Mediated Delivery of CRISPR‐Cas9 Ribonucleoprotein and Long DNA Transgenes Into Primary Blood Cells

Advanced NanoBiomed Research, EarlyView.
CRISPR/Cas9 has revolutionized the field of gene therapy, but delivery remains an outstanding issue. We propose a nonviral gold‐nanoparticle platform for co‐delivery of CRISPR/Cas9 ribonucleoprotein and long 2.1 kilobase dsDNA transgene constructs. This CRISPR‐AuNP is inexpensive to produce and mediate gene editing and DNA delivery in T cells and CD34+
Rachel A. Cunningham, Karthikeya S. V. Gottimukkala, Daniel D. Lane, Katrina Poljakov, Patricia Lipson, Mark R. Enstrom, Alessandro Rizzi, Aude G. Chapuis, Jennifer E. Adair   +8 more
wiley   +1 more source

Intra‐ and interspecific variation in trace element concentrations in feathers of north European trans‐African migrants

Journal of Avian Biology, 2023
The knowledge of migratory connectivity is important for understanding the potential drivers of populations and it is thus important for conservation implications.
Nicolas Ordax Sommer, Arto Luttinen, Aleksi Lehikoinen   +2 more
doaj   +1 more source

In‐vitro puncture experiment using alligator teeth tracks the formation of dental microwear and its association with hardness of the diet

The Anatomical Record, EarlyView.
Abstract With the development of dental microwear texture analysis (DMTA), there has been an increasing application of DMTA for dietary estimation in extant and fossil reptiles, including dinosaurs. While numerous feeding experiments exist for herbivorous mammals, knowledge remains limited for carnivorous reptiles. This study aimed to qualitatively and
K. Usami, M. O. Kubo
wiley   +1 more source

Age differences in primary moult of the Black-headed Gull Chroicocephalus ridibundus

The European Zoological Journal
Flight feather moult is an energetically expensive stage of the annual cycle of birds. Its timing is adjusted to other important time- and energy-demanding activities, including migration.
W. Meissner, M. Jewuła
doaj   +1 more source

Broadening the semiaquatic scene: Quantification of long bone microanatomy across pinnipeds

The Anatomical Record, EarlyView.
Abstract Investigations of bone microanatomy are commonly used to explore lifestyle strategies in vertebrates. While distinct microanatomical limb bone features have been established for exclusively aquatic and terrestrial lifestyles, identifying clear patterns for the semiaquatic lifestyle remains more challenging.
Apolline Alfsen, Christian de Muizon, Olivier Lambert, Giovanni Bianucci, Antonia R. Kaffler, Matthew R. McCurry, Alexandra Houssaye, Rafael M. Varas‐Malca, Rodolfo Salas‐Gismondi, Oliver Hampe, Eli Amson   +10 more
wiley   +1 more source

Seabird moult timing and duration: Implications for at-sea threat exposure worldwide

Global Ecology and Conservation
Tubenosed seabirds (order procellariforms) are the most threatened bird group. Threats generally act on two distinct elements of their life-history, either breeding at terrestrial colonies, or during the nonbreeding season while at sea foraging and ...
Peter Allen, Anne Peters, Zali Stiefel, Rohan H. Clarke   +3 more
doaj   +1 more source

Osteohistology of two phorusrhacids reveals uninterrupted growth strategy

The Anatomical Record, EarlyView.
Abstract Phorusrhacidae were apex predators that primarily dominated South America ecosystems for at least 40 million years with their imposing size and predatory lifestyle—yet some aspects of their biology remain poorly understood. Osteohistology is a tool for understanding growth dynamics and biomechanical adaptations.
Lotta Dreyer, Christian Cooper, Jingmai O'Connor   +2 more
wiley   +1 more source

Fasting and Refeeding Mediated Phospholipid Remodeling Plays an Important Role in Improving Meat Quality of Aged Laying Hens

Animal Research and One Health, EarlyView.
ABSTRACT This study explored fasting‐induced physiological remodeling effects on meat quality in aged laying hens. Fasting for 15 days (F15) significantly reduced abdominal fat, intermuscular fat width, subcutaneous fat thickness, and liver index versus pre‐fasting (F0) (p < 0.05), which recovered post‐refeeding.
Xiaoran Zhang, Jun Zhang, Yadong Tian, Donghua Li, Yanhua Zhang, Lujie Zhang, Yujie Gong, Xiangtao Kang, Ruirui Jiang   +8 more
wiley   +1 more source

Integration of Nutrition and Organic Agriculture Framework in Managing Gastrointestinal Nematodes in Ruminants

Animal Research and One Health, EarlyView.
Gastrointestinal nematode infections damage the gastrointestinal epithelial tissues of ruminants, affecting nutrient utilization and overall production performance. This review outlines host‐gastrointestinal nematode interactions and discusses integrated control strategies, including nutritional supplementation, grazing management, vaccines, and ...
Wenxun Chen, Xiangfang Tang, Yimin Zhuang, Shengjun Zhao, Ying Ren, Xiaokang Lv   +5 more
wiley   +1 more source

Use of Clotrimazole in Finfish Aquaculture: Mechanistic Insights, Limitations, and Future Directions for Antifungal Therapy

Animal Research and One Health, EarlyView.
This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen, Debashri Mondal, Thangapalam Jawahar Abraham   +2 more
wiley   +1 more source