Results 51 to 60 of about 24,128 (305)

HSP70 Interactome‐Mediated Proteolysis Targeting Chimera (HSP70‐PROTAC) for Ferroptosis‐Driven Cancer Treatment

Advanced Science, EarlyView.
This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong, Yulong Li, Hui Liang, Zumei Wu, Shiqun Wang, Yichao Wang, Jieyu Xu, Yanning Lan, Maohua Cai, Guangzhao Pan, Haiyan Yang, Kai Miao, Zhe‐Sheng Chen, Fangfang Tao, Xuelei Ma, Jiang‐Jiang Qin   +15 more
wiley   +1 more source

Somatotrophs and lactotrophs: an immunohistochemical study of Gallus domesticus pituitary gland at different stages of induced moult

European Journal of Histochemistry, 2010
The objective of this study was to determine the distribution of somatotrophs and lactotrophs and conduct a morphometrical analysis of immunoreactive somatotrophs and lactotrophs in the pituitary glands of White Leghorn Hens (Gallus domesticus) during ...
M. A. Sandhu, Z. U. Rahman, A. Riaz, S. U. Rahman, I. Javed, N. Ullah   +5 more
doaj   +1 more source

Non‐moulted primary coverts correlate with rapid primary moulting

Journal of Avian Biology, 2016
Time constraint is a main factor which affects the moult strategies in passerines, mainly during the first year of life. The variability of moult strategies between species is associated with the extent of the moult. In the first year of life, the extent of the moult is highly variable between species and individuals.
Yosef Kiat, Ido Izhaki
openaire   +1 more source

Discovery of SKP2‐Recruiting PROTACs for Target Protein Degradation

Advanced Science, EarlyView.
Based on the SKP2‐targeting ligand SL1, we designed non‐covalent PROTACs by linking it with the BRD4 inhibitor JQ1 and the AR antagonist AL through a linker. These PROTACs successfully induced the ubiquitination of BRD4 and AR, followed by proteasome‐mediated degradation.
Guanjun Dong, Aima Huang, Ziqing Zhao, Bikai Lai, Xin Pan, Huiyu Yang, Xiaohan Xu, Tianwei Wang, Fangchen Zhao, Zhimin Zhang, Yongbo Xue, Guanjun Deng, Wenbin Deng, Jianwei Chen   +13 more
wiley   +1 more source

Sensing Pre- and Post-Ecdysis of Tropical Rock Lobsters, Panulirus ornatus, Using a Low-Cost Novel Spectral Camera

Journal of Marine Science and Engineering
Tropical rock lobsters (Panulirus ornatus) are a highly cannibalistic species with intermoult animals predominantly attacking animals during ecdysis (moulting).
Charles Sutherland, Alan D. Henderson, Dean R. Giosio, Andrew J. Trotter, Greg G. Smith   +4 more
doaj   +1 more source

Detailed morphobiometric studies of Bursaphelenchus xylophilus and characterisation of other Bursaphelenchus species (Nematoda: Parasitaphelenchidae) associated with Pinus pinaster in Portugal [PDF]

, 2007
Detailed studies on Bursaphelenchus xylophilus are provided in this contribution. Comparative observations between field and cultured populations of this species demonstrated significant size differences: cultured specimens overall displayed larger size ...
Bravo, Maria Antónia, Mota, Manuel, Penas, Ana Catarina, Valadas, Vera   +3 more
core  

Iron/Cobalt Dual‐Atom Catalyst Orchestrate Photothermal‐Chemodynamic Immunotherapy Against MRSA: Multi‐Omics Dissection in Murine and Porcine Models

Advanced Science, EarlyView.
FeCo dual‐atom catalyst (FeCo‐N‐DAC) with ultrahigh metal loading (Fe > 5.4%, Co > 4.8%) is developed for synergistic photothermal‐chemodynamic immunotherapy. FeCo‐N‐DAC penetrates deep‐seated tissues, eradicates MRSA biofilms, and reprograms immune‐inflammatory pathways via multi‐omics‐validated mechanisms.
Shihao Xu, Binge Huang, Hao Lin, Jinming Li, Zhaoxiang Lu, Qi Zhang, Jia Li, Shiping Yang, Songsong Lan, Yan Yang, Yun Feng, Xiaojun He   +11 more
wiley   +1 more source

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Doehl et al. discovered an adaptive neuroimmune mechanism that induces itch in tick‐exposed guinea pigs, enabling rapid tick removal. This itch‐induced tick removal (IITR) is mediated by an adaptive cellular immune response and is independent of IgG, IgE, or TRPV1.
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

Flight feather moult in Western Marsh Harriers during autumn migration

Avian Research, 2019
Background Most of long-distance migratory raptors suspend moult during migration but detailed information is patchy for most of the Palearctic species.
Juan Ramírez, Michele Panuccio
doaj   +1 more source

Ecotoxicological studies of selected agrochemicals on the moulting stages of Cyphoderus javanus under laboratory conditions

Environment Conservation Journal, 2023
Indiscriminate use of toxic pesticides in agriculture has raised serious concerns worldwide, which led to a steady destruction of soil biota as well as the overall health of ecosystem. The present study was designed to evaluate the effects of selected
Bhavya LR, M.G. Sanal Kumar
doaj   +1 more source