Results 61 to 70 of about 1,655,584 (304)

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

Future bathroom: A study of user-centred design principles affecting usability, safety and satisfaction in bathrooms for people living with disabilities [PDF]

, 2011
Research and development work relating to assistive technology 2010-11 (Department of Health) Presented to Parliament pursuant to Section 22 of the Chronically Sick and Disabled Persons Act ...
Burton, Maria, Chamberlain, Paul, Mountain, Gail, Reed, Heath   +3 more
core  

A quantitative trait locus analysis of personality in wild bighorn sheep [PDF]

, 2013
Acknowledgments This study was supported by an Alberta Conservation Association grant to JP and Natural Sciences and Engineering Council of Canada (NSERC) discovery grants to DWC, MF and Fanie Pelletier.
Beavis, Bell, Beraldi, Beraldi, Beraldi, Boyko, Clutton-Brock, Colosimo, Dingemanse, Ellegren, Flint, George, Gilmour, Glenske, Gutiérrez, Heath, Hiendleder, Johnston, Johnston, Jorgenson, Kendler, Kruuk, Lander, Lander, Lynch, Marshall, Meyer-Lindenberg, Munafo, Oers, Oers, Penke, Poissant, Poissant, Poissant, Réale, Réale, Réale, Réale, Schielzeth, Schmutz, Sih, Slate, Slate, Slate, Smith, Tarka, Valdez, Wang, Wilson, Wolf, Yang   +50 more
core   +2 more sources

Comparative Oligo‐FISH Mapping Illuminates Chromosomal Evolution Among Rutaceae Species Diverged Over 50 Million Years

Advanced Science, EarlyView.
Oligonucleotide‐based fluorescence in situ hybridization probes were developed in the model citrus species Citrus maxima. These probes were applied to comparative karyotyping across 14 species in the Rutaceae family. This analysis revealed chromosomal evolution in lineages that diverged from Citrus nearly 52 million years ago.
Li He, Hainan Zhao, Xiaoxue Zeng, Zujun Yang, Wenting Li, Guoyan Zhang, Guangrong Li, Jian He, Bin Guan, Jiming Jiang   +9 more
wiley   +1 more source

Controverses en montagne autour d’un chorten, d’une télécabine et des croix

Géographie et Cultures, 2014
This article deals with controversies among various actors that have emerged about three objects. Through these objects, these actors defend sometimes conflicting interests.
Mathieu Petite
doaj   +1 more source

Culture and activity in aging

, 2007
The cumulative effects of illness and disability in older age can lead to individuals being less able to make positive decisions about involvement in activities for pleasure and socialization.
Mountain, Gail, Tetley, Josie
core  

Improved estimate of the detectability of gravitational radiation from a magnetically confined mountain on an accreting neutron star [PDF]

, 2009
We give an improved estimate of the detectability of gravitational waves from magnetically confined mountains on accreting neutron stars. The improved estimate includes the following effects for the first time: three-dimensional hydromagnetic ("fast ...
A. Melatos, Abbott, Abbott, Akgün, Alpar, Andersson, Bildsten, Brown, Buonanno, Burderi, Chakrabarty, Chamel, Choudhuri, Chung, Cumming, Cumming, Cutler, Cutler, Cutler, Furth, Haensel, Haensel, Hanasz, Haskell, Hayes, Jahan-Miri, Jaranowski, Jones, Jones, Konar, Lai, Lai, Link, Litwin, M. Vigelius, Melatos, Melatos, Melatos, Nayyar, Owen, Owen, Payne, Payne, Payne, Payne, Pons, Romani, Schatz, Shibazaki, Stairs, Stergioulas, Thorne, Ushomirsky, Van Den Broeck, Vigelius, Vigelius, Watts, Zhang, Zhang, Zimmermann, Zimmermann   +60 more
core   +1 more source

Mapping the “Supply–Demand–Flow” of Ecosystem Services for Ecosystem Management in China

Advanced Science, EarlyView.
This study develops a “supply–demand–flow” framework clarifies how ecosystem services move between regions by distinguishing potential and actual supply and demand. Using integrated biophysical–socioeconomic modeling, nine services in China were mapped.
Yikun Zhang, Yadong Yang, Yongsheng Wang, Guirui Yu   +3 more
wiley   +1 more source

Conceptualising quality early childhood education: Learning from young children in Brazil and South Africa through creative and play‐based methods

British Educational Research Journal, EarlyView., 2023
Abstract Early childhood has increasingly been acknowledged as a vital time for all children. Inclusive and quality education is part of the United Nations Sustainable Development Goals, with the further specification that all children have access to quality pre‐primary education.
Laura H. V. Wright, Irene Rizzini, Malibongwe Gwele, Lynn McNair, Cristina Laclette Porto, Marsha Orgill, E. Kay M. Tisdall, Malcolm Bush, Linda Biersteker   +8 more
wiley   +1 more source

Les associations foncières pastorales : un dispositif de gouvernance concrète du foncier dans les territoires de montagne

EchoGéo, 2018
The pastoral land associations are tools of land restructuring created by the pastoral law of 1972 to propose a solution to the specific problems of the land in mountain (division, joint possessions, absentee owners).
Laurence Barthe, Corinne Eychenne
doaj   +1 more source