Results 31 to 40 of about 37,039 (263)

A Study on the Time–Effect and Dose–Effect Relationships of Polysaccharide from Opuntia dillenii against Cadmium-Induced Liver Injury in Mice

Foods, 2022
The purpose of this study was to evaluate the protective effect of Opuntia dillenii (Ker-Gaw) Haw. polysaccharide (ODP) against cadmium-induced liver injury.
Ting Liu, Bianli Li, Xin Zhou, Huaguo Chen   +3 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Effects of different cultivation methods on the rhizosphere microbial community and secondary metabolites of Houttuynia cordata Thunb. [PDF]

PeerJ
This study aimed to investigate the effects of three distinct cultivation methods on the plant-soil system of Houttuynia cordata Thunb. specifically focusing on how they shape the rhizosphere microbial community and influence the accumulation of it is ...
Fangmei Song, Die Fu, Anping Wang, Zhannan Yang, Tianhua Yu   +4 more
doaj   +2 more sources

The complete chloroplast genome of Impatiens mengtszeana (Balsaminaceae), an endemic species in China

Mitochondrial DNA. Part B. Resources, 2022
Impatiens mengtszeana is an endemic species in China. In this study, the complete chloroplast genome of I. mengtszeana was sequenced and analyzed. The total chloroplast genome size of I.
Baizhu Li, Yu Li, Zhaofeng Li, Mengda Xiang, Xi Dong, Xiaoxin Tang   +5 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Separation, Purification, Structural Characterization and Hypoglycemic Effect Study of Homogeneous Mori fructus Polysaccharide

Foods
Background/Objectives: Mori fructus polysaccharides are key bioactive components with diverse activities, but structural characterization of homogeneous fractions remains limited, hindering insights into structure–activity relationships.
Qingfang Deng, Yuanyuan Huang, Wen Xie, Jiawen Li, Ting Tang, Xin Zhou   +5 more
doaj   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Forest Age Estimation by Integrating Tree Species Identity and Multi-Source Remote Sensing: Validating Heterogeneous Growth Patterns Through the Plant Economic Spectrum Theory

Remote Sensing
Current mainstream remote sensing approaches to forest age estimation frequently neglect interspecific differences in functional traits, which may limit the accurate representation of species-specific tree growth strategies.
Xiyu Zhang, Chao Zhang, Li Zhou, Huan Liu, Lianjin Fu, Wenlong Yang   +5 more
doaj   +1 more source

The Antioxidant Activities In Vitro and In Vivo and Extraction Conditions Optimization of Defatted Walnut Kernel Extract

Foods, 2023
The objective of this study was to determine the antioxidant activities of defatted walnut kernel extract (DWE) and whole walnut kernel extract (WE) in vitro and in vivo.
Xiaomei Zhou, Xiaojian Gong, Xu Li, Ning An, Jiefang He, Xin Zhou, Chao Zhao   +6 more
doaj   +1 more source