Results 111 to 120 of about 12,888 (261)
Advanced Science, EarlyView.We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel +16 more
wiley +1 more source
Advanced Science, EarlyView.Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng +8 more
wiley +1 more source
Research progress on assessment tools for mouth neoplasms patent⁃reported outcome
Huli yanjiu, 2019 This paper analyzed assessment tools for oral cancer patients⁃reported outcome,reviewed the research status of the patient-reported outcome scale and intended to provide theoretical basis for China’s oral cancer patient⁃reported outcome scale.
GUO Qian, LI Li, HOU Lili
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, 2020 Cancer is a disease that humans have been struggling to combat for centuries. It originates from the accumulation of several mutations over the life of a cell that causes it to evade cell death and multiply rapidly.
Current, Joseph R
core +1 more source
Solid Harmonic Wavelet Bispectrum for Image Analysis
Advanced Science, EarlyView.The Solid Harmonic Wavelet Bispectrum (SHWB), a rotation‐ and translation‐invariant descriptor that captures higher‐order (phase) correlations in signals, is introduced. Combining wavelet scattering, bispectral analysis, and group theory, SHWB achieves interpretable, data‐efficient representations and demonstrates competitive performance across texture,
Alex Brown +3 more
wiley +1 more source
Advanced Science, EarlyView.TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang +17 more
wiley +1 more source
Expression of p53 in the Tumor and Oral Epithelium in Patients with Cancer of Mouth and Pharynx
International Archives of Otorhinolaryngology, 2011 Introduction: Expressive percent of patients with oral and oral pharynx carcinomas presents with overexpression of protein p53 induced by tobacco, alcohol and radiotherapy.
Santos, Fabiane Dittrich +3 more
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Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management
Advanced Science, EarlyView.ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak +9 more
wiley +1 more source
Ocupação e câncer da cavidade oral e orofaringe
Cadernos de Saúde PúblicaEstudo caso-controle conduzido para avaliar a associação de exposições ocupacionais e câncer oral e orofaringe na Região Metropolitana de São Paulo. Inclui 325 casos e 468 controles, recrutados por freqüência de sexo e faixa etária, entrevistados entre ...
Magda Andreotti +5 more
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Pesquisa Brasileira em Odontopediatria e Clínica Integrada, 2021 Objective: To determine the association of socio-demographic and clinic-pathological risk factors with oral cancer in Kelantan, Malaysia. Material and Methods: A 19-year cross-sectional survey was performed in Hospital Universiti Sains Malaysia (HUSM ...
Paras Ahmad +7 more
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