Results 141 to 150 of about 677,185 (349)

Oral cancer in patients of the province of Las Tunas, a 7-year study

open access: yesRevista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2018
Background: oral cancer has become a worldwide health problem, mostly in underdeveloped countries and in certain geographic areas where the incidence and mortality rate are particularly high.Objective: to describe the morbidity in the population ...
Tomás Ramón de-la-Paz-Suárez   +3 more
doaj  

Factors associated with post‑operative complications in oral carcinoma: Prospective study

open access: yesBrazilian Journal of Otorhinolaryngology
Objective: Patients who require surgery to treat head and neck cancer are at higher risk of perioperative complications and this scenario is not different for patients with malignant tumors of the oral cavity. Thus, the objective of the present study was
Paulo Victor Sola Gimenes   +4 more
doaj   +1 more source

Polysaccharide Adjuvants as Innate Immune Trainers: Bridging Pattern Recognition Receptor (PRR) Activation and Metabolic Reprogramming for Synthetic Vaccine Design

open access: yesAdvanced Science, EarlyView.
Polysaccharides modulate immune responses by engaging pattern recognition receptors (PRRs) to induce T‐cell activation. In vaccine design, their particle size critically influences lymph node targeting and activation mechanisms. By engineering structural complexity and multivalent PRR engagement, polysaccharides enable precise modulation of immune ...
Jeong Hyun Moon   +8 more
wiley   +1 more source

Bifurcate Regulation of Hematopoietic Homeostasis and Bone Osteogenesis by VHL‐HIF2α‐Controlled Adipocyte Function

open access: yesAdvanced Science, EarlyView.
The VHL‐HIF2α (VHL is Von Hippel‐Lindau) axis in adipocytes differentially regulates hematopoiesis and bone formation through stem cell factor (SCF) and chemerin, respectively. This hypoxia‐responsive pathway in adipocytes establishes a systemic signaling network with HSCs and MSCs to maintain tissue homeostasis, revealing a targetable axis for ...
Qian Li   +6 more
wiley   +1 more source

Preventive Effect of Glycyrrhiza Glabra Extract on Oral Mucositis in Patients under Head and Neck Radiotherapy: A Randomized Clinical Trial

open access: yesFrontiers in Dentistry, 2017
Objectives: About two-thirds of cancer patients undergo radiotherapy. Oral mucositis represents a major complication of radiotherapy, causing morbidity and mortality and decreasing the quality of life of patients.
Shamsolmolok Najafi   +5 more
doaj  

The cost of radiology procedures using Activity Based Costing (ABC) for development of cost weights in implementation of casemix system in Malaysia [PDF]

open access: yes, 2018
Presently there is a gross lack of information on cost and cost weights in many developing countries that implement casemix system. Furthermore, studies that employed Activity Based Costing method (ABC) to estimate the costs of radiology procedures were ...
Amrizal Muhd Nur,   +3 more
core  

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

open access: yesAdvanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang   +15 more
wiley   +1 more source

The Tumor‐to‐Endothelial Transfer of FTO Promotes Vascular Remodeling and Metastasis in Nasopharyngeal Carcinoma

open access: yesAdvanced Science, EarlyView.
Integrated omics analysis of matched primary and liver metastatic NPC tumors reveals a unique NOTCH1+ CSC subpopulation exhibiting enhanced stemness properties and tumorigenic capacity. With in vitro and in vivo assays, exosomal transfer of tumor‐derived FTO from NOTCH1+ cells to the endothelium promotes vascular permeability and metastatic potential ...
Chun Wu   +23 more
wiley   +1 more source

Mapping the Tissue‐of‐Origins of Mesenchymal Stromal Cells in Injury Repair

open access: yesAdvanced Science, EarlyView.
This study maps mesenchymal stromal cells (MSCs) across multiple tissues, revealing that bone marrow–derived MSCs mobilize monocytes via CCL2 to promote systemic inflammation but do not migrate to distant organs to form fibrotic or tumor stroma. Instead, local MSCs dominate tissue remodeling, suggesting a “two‐hit” model linking systemic inflammation ...
Xinyu Thomas Tang   +4 more
wiley   +1 more source

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