Results 171 to 180 of about 85,546 (340)

Spatial Transcriptomics and snRNA‐seq Expose CAF Niches Orchestrating Dual Stromal‐Immune Barriers in Hepatocellular Carcinoma

Advanced Science, EarlyView.
HmmyCAFs may form a triple immunosuppressive niche: possibly secrete ECM (POSTN, etc.) as physical barriers to block CD8⁺ T cells, induce CD8⁺ T exhaustion via those molecules, and use HIF‐1α‐driven metabolism to create acidic, nutrient‐poor microenvironments that suppress T cells.
Yingxue Li, Changxiang Huan, Haoting Sun, Wei Zhang, Zhen Guo, Chuanyu Li, Jia Yao, Zhiqi Zhang, Shizhe Yu, Qiongzhu Dong, Lunxiu Qin, Jinze Li, Lianqun Zhou   +12 more
wiley   +1 more source

Adenomatoid Hyperplasia Requiring Differential Diagnosis From Malignant Neoplasms: A Report of Two Cases. [PDF]

Cureus
Kimura T, Shimura T, Kato Y, Yanagawa-Matsuda A, Kawamura K, Tanei ZI, Tanaka S, Sakata KI.   +7 more
europepmc   +1 more source

Dual‐Pedicle Tissue‐Engineered Trachea Promotes Biomimetic Cartilaginous Framework, Vascularization, and Epithelial Lining for Long‐Segment Tracheal Reconstruction

Advanced Science, EarlyView.
Overcoming the limitations of conventional grafts, a biomimetic trachea with two independent vascular pedicles enables rapid integration and sustained patency. This approach markedly improves survival rates, restores the epithelial barrier, and promotes regenerative pathways, presenting a transformative paradigm for clinical application.
Ziming Wang, Yuming Wang, Zihao Chen, Erji Gao, Liang Guo, Juanjuan Li, Siqiang Zheng, Jiaoyu Yi, Zhe‐Sheng Chen, Bo Tao   +9 more
wiley   +1 more source

The pursuit of novel head and neck cancer biomarkers - tissue and blood expression of chloride intracellular channels family. [PDF]

PLoS One
Wojtera BP, Ostrowska K, Ostapowicz J, Szewczyk M, Kozikowska J, Suchorska WM, Golusiński W.   +6 more
europepmc   +1 more source

Nanoscopic Mapping of the Extracellular Space in Amyloid Plaque‐rich Cortex

Advanced Science, EarlyView.
The extracellular space and diffusion around amyloid plaques are examined using shadow imaging and single‐particle tracking. Increased diffusivity is found near plaques, extracellular matrix alterations, and plaque core penetrability that varies with amyloid phenotype.
Juan Estaún‐Panzano, Yulia Dembitskaya, Ivo Calaresu, Somen Nandi, Quentin Gresil, Evelyne Doudnikoff, Thierry Leste‐Laserre, Thierry Amédée, Laurent Cognet, Laurent Groc, Urs Valentin Nägerl, Erwan Bezard   +11 more
wiley   +1 more source

Widening socioeconomic inequalities in cancer incidence and related potential to reduce cancer between 2008 and 2019 in Germany. [PDF]

Sci Rep
Tetzlaff F, Barnes B, Jansen L, Peters F, Schultz A, Katalinic A, Kraywinkel K, Michalski N, Nowossadeck E, Hoebel J.   +9 more
europepmc   +1 more source

Micro/Nanorobots for Combating Brain Disorders: Challenges, Advances, and Perspectives

Advanced Science, EarlyView.
Micro/nanorobots (MNRs) offer a transformative approach for precision therapy in brain disorders. By overcoming biological barriers and enabling controlled propulsion, targeted delivery, and real‐time imaging/tracking, MNRs pave the way toward effective, minimally invasive treatments. This review outlines the interplay between brain disease challenges,
Qi Zhang, Dong Sun
wiley   +1 more source

Dexmedetomidine target-controlled infusion-based sedoanalgesic technique for awake craniotomy in brain neoplasms: A case series. [PDF]

Indian J Anaesth
Shah SB, Chawla R, Kaur C, Bhasin N.
europepmc   +1 more source

Discrepancy Between Radiographic and Pathological Response Assessment in Neoadjuvant Treatment for Pancreatic Cancer: A Comparison Between Neoadjuvant Chemotherapy and Neoadjuvant Chemoradiotherapy

Annals of Gastroenterological Surgery, EarlyView.
This study investigated the association between radiographic and pathological response assessments among patients with pancreatic cancer receiving neoadjuvant chemotherapy and neoadjuvant chemoradiotherapy. The present study revealed that discrepancies between radiographic and histological responses may differ according to the type of therapy ...
Satoru Miyahara, Hidenori Takahashi, Yoshito Tomimaru, Shogo Kobayashi, Daisaku Yamada, Hirofumi Akita, Takehiro Noda, Yuichiro Doki, Hidetoshi Eguchi   +8 more
wiley   +1 more source

Health‐related quality of life following total minimally invasive, hybrid minimally invasive or open oesophagectomy: a population‐based cohort study

BJS (British Journal of Surgery), EarlyView., 2020
All patients operated for oesophageal cancer in Sweden from 2013 to April 2018 were identified, and 246 patients were recruited to this population‐based nationwide Swedish study. The results show that longitudinal health‐related quality of life after minimally invasive oesophagectomy was similar to that of the open surgical approach.
F. Klevebro, J. H. Kauppila, S. Markar, A. Johar, P. Lagergren   +4 more
wiley   +1 more source