Results 131 to 140 of about 157,233 (348)

GOT1 Inhibition Induces Extracellular Matrix Remodeling in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
Using tumor tissue engineering, we recreated pancreatic cancer and found that inhibiting glutamic‐oxaloacetic transaminase 1 (GOT1) induces extracellular matrix remodeling and secretome rewiring, as well as promotes cell death. ABSTRACT Pancreatic cancer cells rely on glutamine to sustain their survival in the stiff and poorly vascularized tumor ...
Rodrigo Curvello   +10 more
wiley   +1 more source

EIF5A Couples Translational Control With Transcriptional Reprogramming Through Chromocenter Reorganization During Spermiogenesis

open access: yesAdvanced Science, EarlyView.
The translation factor Eukaryotic translation initiation factor 5A (eIF5A) is essential for male fertility in mice. It supports the translation of proteins crucial for heterochromatin organization and acrosome formation. eIF5A deficiency disrupts chromocenter integrity, increases chromatin accessibility, and causes transcriptional dysregulation ...
Yuling Cai   +15 more
wiley   +1 more source

3D‐Printed Ion‐Conductive Hydrogels with Tunable Mechanical–Electrical Properties for Multimodal Sign Language Recognition

open access: yesAdvanced Science, EarlyView.
This work successfully fabricated ion‐conductive hydrogels with low hysteresis and high conductivity using 3D printing technology. By adjusting the component ratios, the properties of the hydrogels can be tuned to meet diverse sensing requirements. Finally, a multimodal sensing sign language recognition system was constructed based on this hydrogel ...
Quan Hu   +9 more
wiley   +1 more source

One-Stop Accessibility: A Nationwide Survey of One-Stop Centers on Services for People with Disabilities [PDF]

open access: yes, 2002
The purpose of this study is to ascertain the accessibility status of One-Stop centers andthe ways that workforce development systems are serving people with disabilities.
Ariana Funaro, Duke Storen, K. A. Dixon
core  

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

open access: yesAdvanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo   +5 more
wiley   +1 more source

Influence of oral health condition on swallowing and oral intake level for patients affected by chronic stroke

open access: yesClinical Interventions in Aging, 2014
Cláudia T Mituuti,1 Vinicius C Bianco,2 Cláudia G Bentim,3 Eduardo C de Andrade,1 José H Rubo,2 Giédre Berretin-Felix1 1Speech Language and Hearing Department, 2Department of Prosthodontics, Bauru School of Dentistry ...
Mituuti CT   +5 more
doaj  

Full-Mouth Rehabilitation Using All-Ceramic Restorations.

open access: yesCompendium of continuing education in dentistry (Jamesburg, N.J. : 1995), 2017
The scientific and technological advancement of cosmetic dentistry has improved metal-free ceramic systems for fixed prosthodontics as well as porcelain veneers, making them an excellent treatment option for delivering superior cosmetic results. The authors present a clinical case of full-mouth rehabilitation using all-ceramic restorations with ...
Luvizuto, Eloá R   +6 more
openaire   +2 more sources

In Situ Liquid‐Cell Transmission Electron Microscopy Insights Into Lithium‐Ion Battery Materials Degradation: Challenges and Emerging Solutions

open access: yesAdvanced Science, EarlyView.
Lithium‐ion battery degradation arises from complex, localized processes during operation, limiting long‐term performance. In situ electrochemical liquid cell TEM provides unique access to these mechanisms. This review summarizes degradation phenomena revealed by liquid cell TEM, traces the evolution of the three main cell designs, compares their ...
Walid Dachraoui, Rolf Erni
wiley   +1 more source

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