Results 181 to 190 of about 8,270,084 (301)

Beyond structure prediction: Translating D-I-TASSER models into functional and mechanistic hypotheses. [PDF]

Clin Transl Med
Mo Y, Jia T, Zhang Y.
europepmc   +1 more source

Structure Validation: A Moving Target [PDF]

Acta Crystallographica Section A Foundations of Crystallography, 2000
D. J. Watkin, R. Cooper, C. K. Prout
openaire   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Dual-Model Artificial Intelligence Framework Integrating AI-Based Markerless Motion Capture for Dynamic Gait Prediction and Health-Status Classification. [PDF]

Diagnostics (Basel)
Rodríguez-Granados EJ, Urriolagoitia-Sosa G, Romero-Ángeles B, Gomez-Niebla JA, Guereca-Ibarra JR, Suarez-Hernandez ML, Rocha-Martinez MN, Carmona-Hernández EE, Lugo-Chacon LI, Ramirez-Sanchez G.   +9 more
europepmc   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

DreamFold: A World Model to efficiently generate protein folding pathways in the latent space. [PDF]

Protein Sci
Ianeselli A, Im J, Cavallin E, Gerstein MB.   +3 more
europepmc   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Embodied groove-synchrony model: movement context reshapes groove-synchrony coupling and its dominant timescale. [PDF]

Front Psychol
Tanabe H, Nakajima M, Shiratori M, Yamamoto K, Okano M.   +4 more
europepmc   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

From parasite to bridge: redefining Cuscuta in plant communication networks. [PDF]

Mol Hortic
Eom SH, Hyun TK.
europepmc   +1 more source