Results 41 to 50 of about 289,331 (311)

TRAUMATISED OLDER PERSONS’ EXPERIENCES OF EYE MOVEMENT INTEGRATION AS TRAUMA INTERVENTION

open access: yesSocial Work/Maatskaplike Werk, 2021
The world’s population is ageing and older people may be exposed to traumatic experiences during their lifetime. Symptoms are often regarded as part of the ageing process and not treated as trauma.
Andrea Visagie, Annaline Keet
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

Voluntary Initiation of Movement: Multifunctional Integration of Subjective Agency

open access: yesFrontiers in Psychology, 2015
This paper investigates subjective agency (SA) as a special type of efficacious action consciousness. Our central claims are, firstly, that SA is a conscious act of voluntarily initiating bodily motion.
Patrick eGrüneberg   +3 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Estimating the real burden of gestational syphilis in Brazil, 2007–2018: a Bayesian modeling studyResearch in context

open access: yesThe Lancet Regional Health. Americas, 2023
Summary: Background: Although several studies have estimated gestational syphilis (GS) incidence in several countries, underreporting correction is rarely considered.
Guilherme Lopes de Oliveira   +12 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Reflections on integrative and comparative movement neuroscience [PDF]

open access: yesIntegrative and Comparative Biology, 2007
Integrative movement neuroscience involves blending "inside-out" and "outside-in" approaches in the study of posture and movement. The former is characterized by determining the properties of single cells within the central nervous system (CNS) and then ascertaining how these properties influence the operation of CNS microcircuits, single reflexes ...
openaire   +2 more sources

‘Integration’ as a Process of Inclusion for Migrants? The Case of Long-Term Residents in the EU. CEPS Working Documents No. 219, 1 March 2005 [PDF]

open access: yes, 2005
At a time when the development of a common EU immigration policy remains far from a reality, the integration of migrants has been placed at the very top of the EU agenda.
Carrera, Sergio
core  

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

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