Results 111 to 120 of about 7,874,951 (392)
npj Parkinson's Disease, 2023 Elevated urine bis(monoacylglycerol)phosphate (BMP) levels have been found in gain-of-kinase function LRRK2 G2019S mutation carriers. Here, we have expanded urine BMP analysis to other Parkinson’s disease (PD) associated mutations and found them to be ...
Sara Gomes +21 more
doaj +1 more source
Dopamine dysregulation in a mouse model of paroxysmal nonkinesigenic dyskinesia. [PDF]
, 2012 Paroxysmal nonkinesigenic dyskinesia (PNKD) is an autosomal dominant episodic movement disorder. Patients have episodes that last 1 to 4 hours and are precipitated by alcohol, coffee, and stress.
Edwards, Robert H +10 more
core +2 more sources
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
The Arabidopsis synaptotagmin SYTA regulates the cell-to-cell movement of diverse plant viruses
Frontiers in Plant Science, 2014 Synaptotagmins are a large gene family in animals that have been extensively characterized due to their role as calcium sensors to regulate synaptic vesicle exocytosis and endocytosis in neurons, and dense core vesicle exocytosis for hormone secretion ...
Asako eUchiyama +5 more
doaj +1 more source
Communications Biology, 2022 GBA variants carriers are at increased risk of Parkinson’s disease (PD) and Lewy body dementia (LBD). The presence of pseudogene GBAP1 predisposes to structural variants, complicating genetic analysis.
Marco Toffoli +12 more
doaj +1 more source
Protein disulfide isomerase activity is essential for viability and extracellular matrix formation in the nematode Caenorhabditis elegans. [PDF]
, 2007 Protein disulfide isomerase (PDI) is a multifunctional protein required for many aspects of protein folding and transit through the endoplasmic reticulum.
Alan D. Winter +44 more
core +1 more source
Signaling in plants by intercellular RNA and protein movement [PDF]
Genes & Development, 2002 Plants and animals have had about 1.6 billion years—the time that has passed since they diverged from their last unicellular ancestor—to evolve different mechanisms for solving unique problems of development and intercellular signaling. As an example, plant cells are separated from each other by a substantial extracellular matrix, the cell wall ...
Xuelin Wu +2 more
openaire +3 more sources
Brucella NyxA and NyxB dimerization enhances effector function during infection
FEBS Letters, EarlyView.Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre +4 more
wiley +1 more source
The Plant Cell, 2010 Viral movement proteins (MPs) enable viral pathogens to pass through cell walls by increasing the size exclusion limit (SEL) of plasmodesmata (PD). Cucumber mosaic virus (CMV) MP was found to bind and sever actin filament (F-actin) in vitro, and such ...
S. Su +8 more
semanticscholar +1 more source
Viruses, 2018 The Luteoviridae is an agriculturally important family of viruses whose replication and transport are restricted to plant phloem. Their genomes encode for four proteins that regulate viral movement.
Stacy L. DeBlasio +6 more
doaj +1 more source