Results 111 to 120 of about 562,130 (302)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Genetic and biological characterisation of a Grapevine virus A isolate from the Czech Republic

Plant Protection Science, 2008
An isolate of Grapevine virus A (GVA) from the Czech Republic was obtained from the grapevine cultivar Müller Thurgau. Symptoms of GVA - Kober stem grooving disease were not observed in the infected grapevines (which had been grafted onto Kober 5BB ...
Petr KOMÍNEK, Marcela KOMÍNKOVÁ
doaj   +1 more source

Water and Protein Movements in Ligand-Receptor Interactions [PDF]

Journal of Biological Physics, 2002
I have recently developed a novel method `mutual repulsion' for simulating ligand unbindingfrom receptor. Combined with adiabatic switching,this method can evaluate the free energy change of unbinding. Mutualrepulsion has been applied to the bovine serum retinol-bindingprotein-retinol complex (1HBP). Large changes in amino acid configurationis observed
openaire   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Tobamovirus 3′-Terminal Gene Overlap May be a Mechanism for within-Host Fitness Improvement

Frontiers in Microbiology, 2017
Overlapping genes (OGs) are a universal phenomenon in all kingdoms, and viruses display a high content of OGs combined with a high rate of evolution. It is believed that the mechanism of gene overlap is based on overprinting of an existing gene. OGs help
Yuri L. Dorokhov, Yuri L. Dorokhov, Ekaterina V. Sheshukova, Tatiana V. Komarova, Tatiana V. Komarova   +4 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

A beta-herpesvirus with fluorescent capsids to study transport in living cells. [PDF]

, 2012
Fluorescent tagging of viral particles by genetic means enables the study of virus dynamics in living cells. However, the study of beta-herpesvirus entry and morphogenesis by this method is currently limited.
Lisa Marcinowski, Marcinowski, Lisa, Ulrich H Koszinowski, Christophe Jung (152124), Jens von Einem, Gaul, Ulrike, Paul Walther, Einem, Jens von, Jens B Bosse, Paul Walther (113867), Ruzsics, Zsolt, Ulrike Gaul, Ulrich H. Koszinowski (152143), Bosse, Jens B., Zsolt Ruzsics (75383), Leonhard Popilka (152101), Leonhard Popilka, Christophe Jung, Jens B. Bosse (138966), Lisa Marcinowski (138962), Jens B. Bosse, Martina Taeglich (152115), Rudolf Bauerfeind (152093), Taeglich, Martina, Koszinowski, Ulrich H., Hannah Striebinger, Zsolt Ruzsics, Ulrike Gaul (3154), Ulrich H. Koszinowski, Jung, Christophe, Hannah Striebinger (152128), Martina Taeglich, Jens von Einem (152134), Bauerfeind, Rudolf, Striebinger, Hannah, Rudolf Bauerfeind, Walther, Paul, Popilka, Leonhard   +37 more
core   +1 more source

The Interaction Dynamics of Two Potato Leafroll Virus Movement Proteins Affects Their Localization to the Outer Membranes of Mitochondria and Plastids

Viruses, 2018
The Luteoviridae is an agriculturally important family of viruses whose replication and transport are restricted to plant phloem. Their genomes encode for four proteins that regulate viral movement.
Stacy L. DeBlasio, Yi Xu, Richard S. Johnson, Ana Rita Rebelo, Michael J. MacCoss, Stewart M. Gray, Michelle Heck   +6 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Structural studies of protein deposition in developing legume seeds [PDF]

, 1983
A comparative study of storage protein deposition has been made in developing seeds of a range of legumes. Varieties of pisum sativum, vicia faba, vigna unguiculata, and Phaseolus vulgaris have been examined.
Bakhtiar, A.
core