Results 31 to 40 of about 4,282,757 (297)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

THE SOUTH AFRICAN ‘WAR RESISTANCE’ MOVEMENT 1974–1994

Scientia Militaria, 2015
From the mid-1970s until the onset of negotiations to end apartheid in 1990, escalating military conflict in the Southern African region was accompanied by a steady increase of conscription dependent on the white male population in South Africa. This was
Gavin Cawthra
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The Sikep Resistance as an Anti-Colonial Movement

Fajar Historia: Jurnal Ilmu Sejarah dan Pendidikan
In the late 19th century, various social resistance movements emerged among Javanese farmers one of these was the Sedulur Sikep, or Saminis movement, meanwhile the Dutch East Indies government carried out a propaganda campaign through colonial ...
Firza Azzam Fadilla, Daya Negri Wijaya, Muhammad 'Afwan Mufti   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Comparative analysis of biomechanical characteristics between the new Tai Chi elastic band exercise for opening and closing movement and elastic band resistance training for the reverse fly movement [PDF]

PeerJ
Background The objective of this study was to compare and analyze the representative opening and closing movement of Tai Chi elastic band exercise with the reverse fly movement of elastic band resistance training. The aim was to explore the biomechanical
Mingyu Liu, Cuihan Li, Xiongfeng Li, Jianwei Zhang, Haojie Li, Yameng Li, Qiuyang Wei, Zaihao Chen, Jiahao Fu, Yanying Li, Meize Cui, Lujia Li, Peng Zhang, Yuerong Huang, Yuxin Ma, Jianan Xu, Shaojun Lyu, Yunchao Ma   +17 more
doaj   +2 more sources

A Comparative Study of Reflections of Resistance in the Poetry of Malek-o-Shoara Bahar and Amal Donqol [PDF]

ادبیات تطبیقی, 2017
Resistance literature is usually created in the conditions of oppression, inner despotism, lack of social and individual freedom, defiance of law, and foreign aggression.
Ebrahim Vasheghani Farahani, رضا تواضعی   +1 more
doaj   +1 more source

Political Opportunities in the Samin Movement Against the Establishment of a Cement Factory in Pati

Policy & Governance Review, 2023
The struggle against the hegemony of rulers and extractive companies is still being carried out by indigenous people around the world. Samin is one of the indigenous populations that is still struggling to defend their territory from the establishment of
Winda Septiani, Enkin Asrawijaya
doaj   +1 more source