Results 121 to 130 of about 654,982 (252)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Border Violence as Border Deterrence Condensed Analysis of Violent Push-Backs from the Ground [PDF]
, 2020 Thousands of people on the move, travelling through the Balkan route to Europe, are caught in a cycle of structural violence marked by repeated denials of access to asylum procedures, physical attacks from EU border authorities, and collective expulsions.
Sapoch, Jack, Augustova, Karolina
core
Body of movement : (in)forming movement
, 2017 In dance many choreographers uses neutral garments not to distract too much from the movement the ”natural” body performs. Still these garments paints the body with color, form, identity and movement qualities. The work exemplifies how the body can extend into materiality and through this it questions the borders of the body not only in form, which is ...
openaire +2 more sources
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Concrete and masonry movements /
Widely used in the construction of bridges, dams and pavements, concrete and masonry are two of the world's most utilized construction materials. However, many engineers lack a proper understanding of the methods for predicting and mitigating their ...
Brooks, J. J.,author.
core
Do Changes in Movements after Tool Use Depend on Body Schema or Motor Learning?
, 2010 In a recent study, Cardinali et al. (2009) showed that training the use of a tool affected kinematic characteristics of subsequent free movements (i.e., movement were slower, for instance), which they interpreted as that the use of a tool affects the ...
Bongers, Raoul M. +4 more
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Policy Responses to Exchange-Rate Movements [PDF]
This paper examines policy responses to exchange-rate movements in a simple model of an open economy. The optimal response of monetary policy to an exchange-rate change depends on the source of the change: on whether the underlying shock is a shift in ...
Laurence M. Ball
core