Results 131 to 140 of about 2,380 (175)
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Moxidectin induces autophagy arrest in colorectal cancer
Medical Oncology, 2022Colorectal cancer (CRC) is a cancer with a high morbidity and mortality worldwide. Hence, developing new therapeutic drugs for CRC is very important. Moxidectin (MOX) has shown good anti-glioblastoma effect both in vitro and in vivo. This study aimed to elucidate the anti-CRC effect of MOX and its potential mechanism by investigating the influence of ...
Yushan Mao +5 more
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Responsible use of moxidectin in sheep
Veterinary Record, 2020SCOPS (sustainable control of parasites in sheep) and Zoetis held a joint workshop in September 2019 to discuss how to advise prescribers and sheep farmers on the use of moxidectin, and prioritising the 2 per cent injectable formulation. This was in response to concerns regarding reports of potential overuse, in particular, as a treatment for ewes at ...
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Moxidectin-resistant nematodes in cattle in Brazil
Veterinary Parasitology, 2009The frequent use of anthelmintics in cattle has contributed to the emergence of gastrointestinal nematode populations resistant to the drugs available in the market. This study aimed to evaluate moxidectin efficacy in a property with suspected presence of Oesophagostomum spp. resistant to such anthelmintic.
Condi, G. K. +2 more
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Analytical Profile of Moxidectin
2013Moxidectin or F28249α is a potent endectocide and semisynthetic methoxime derivative of naturally occurring nemadectin. It is well known for the novel mode of action against a broad range of nematode and anthropod animal parasites. In this work, physicochemical and pharmaceutical aspects of moxidectin are described including stability, semisynthesis ...
Atul, Awasthi +4 more
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Journal of Agricultural and Food Chemistry, 1994
The absorption, tissue distribution, excretion, and biotransformation of moxidectin, a novel endectocide that combats internal and external parasites in sheep, cattle, and horse, were studied in sheep. Following a single oral administration of a 1:1 mixture of 14 C- and deuterium-labeled moxidectin at 0.2 mg/g of body weight, the highest residue ...
Jalees Afzal +3 more
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The absorption, tissue distribution, excretion, and biotransformation of moxidectin, a novel endectocide that combats internal and external parasites in sheep, cattle, and horse, were studied in sheep. Following a single oral administration of a 1:1 mixture of 14 C- and deuterium-labeled moxidectin at 0.2 mg/g of body weight, the highest residue ...
Jalees Afzal +3 more
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Safety of moxidectin in avermectin-sensitive Collies
American Journal of Veterinary Research, 2000Abstract Objective—To evaluate the safety of moxidectin administration at doses of 30, 60, and 90 µg/kg of body weight (10, 20, and 30 times the manufacturer's recommended dose) in avermectin-sensitive Collies. Animals—24 Collies. Procedure—Collies with mild to severe reactions to ivermectin challenge (120 mg/kg; 20 times ...
A J, Paul +2 more
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Depletion of Moxidectin Tissue Residues in Sheep
Journal of Agricultural and Food Chemistry, 2000The pattern of tissue depletion of moxidectin (MXD) subcutaneously administered to sheep was characterized in this study. MXD concentration profiles were determined in muscle, fat, and liver and at the site of injection following administration of a formulation combining MXD (0.5% w/v) with a standard 6 in 1 clostridial vaccine.
A, Lifschitz +6 more
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Presumed moxidectin toxicosis in three foals
Journal of the American Veterinary Medical Association, 1999Outcome and complications associated with administration of moxidectin gel to 3 foals < 4 months old are described. Two foals became comatose but survived following supportive treatment. One foal died following loss of consciousness associated with moxidectin administration. Risk of moxidectin overdose exists, because horse owners often fail to read or
P J, Johnson +3 more
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Efficacy of moxidectin against cyathostomins
Veterinary Record, 2009It would be very encouraging if the report of [Schumacher and others (2009)][1] was a true indication of the lack of moxidectin resistance in horses after its use for five years in a heavily stocked pasture, but on the data presented I do not believe that this conclusion can be reached.
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The influence of parasitism on the pharmacokinetics of moxidectin in lambs
Parasitology Research, 2004Most pharmacokinetic studies on anthelmintic drugs have been performed on non-parasitized animals. However, it seems likely that the parasite burden could influence the deposition of such drugs. The pharmacokinetics of moxidectin administered orally and by subcutaneous injection was compared in lambs exposed to nematode infection and in parasite naive ...
Lespine, Anne +4 more
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