Results 71 to 80 of about 1,627 (219)

Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling

open access: yesCytopathology, EarlyView.
Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu   +3 more
wiley   +1 more source

The Role of Endoscopic Ultrasonography (EUS) in Metastatic Tumors in the Pancreas: 10 Years of Experience from a Single High-Volume Center

open access: yesDiagnostics
Background: Metastatic pancreatic lesions (MPLs) are relatively uncommon, constituting 2 to 5% of all pancreatic tumors. They often manifest as solitary lesions without distinct clinical symptoms, usually identified incidentally during radiologic imaging
Alessandro Aversano   +9 more
doaj   +1 more source

RNF13 is a previously undescribed interactor of iduronate 2‐sulfatase that modifies its glycosylation and maturation

open access: yesThe FEBS Journal, EarlyView.
Iduronate 2‐sulfatase (IDS; purple) is expressed as a precursor protein that goes through multiple steps of maturation, modification, and trafficking to become an active lysosomal enzyme that degrades glycosaminoglycans. Our study shows that the transmembrane ubiquitin ligases RNF13 (orange) and RNF167 (pink) heterodimerize, affecting IDS intracellular
Valérie C. Cabana   +4 more
wiley   +1 more source

ОБҐРУНТУВАННЯ ВПРОВАДЖЕННЯ ТЕХНОЛОГІЇ МУЛЬТИПРОТОКОЛЬНОЇ КОМУТАЦІЇ ПО МІТКАМ ЯК ОСНОВИ ТРАНСПОРТНОЇ МЕРЕЖІ ЗВ’ЯЗКУ

open access: yesSučasnì Informacìjnì Tehnologìï u Sferì Bezpeki ta Oboroni, 2014
В статті розглянуті характеристики транспортних мереж і основні вимоги до їх побудови. Проаналізована технологія мультипротокольної комутації по міткам, її архітектура, наведені основні визначення та терміни даної технології.
Mykola M. Fomin, Inna V. Zhytnyk
doaj  

RNF13 regulates the endolysosomal pathway through interaction with the small GTPase Arl8B

open access: yesThe FEBS Journal, EarlyView.
The E3 ubiquitin ligase RNF13 functions as a regulatory scaffold, organizing Arl8B‐dependent complexes and tuning downstream signaling that controls endolysosomal organization and trafficking. In this model, wild‐type RNF13 associates with Arl8B on endolysosomes, whereas Arl8B (E22D/F55A) or RNF13 (L244A) variants weaken complex assembly, potentially ...
Audrey M. Sénécal   +4 more
wiley   +1 more source

Real‐world clinical and laboratory changes after switching to two‐drug regimen in HIV‐suppressed individuals: 48 weeks and beyond

open access: yesHIV Medicine, EarlyView.
Abstract Introduction Two‐drug regimens (2DRs) may reduce long‐term drug toxicities and drug‐drug interactions for people with HIV (PWH) on antiretroviral therapy (ART). This study evaluated clinical and laboratory outcomes in PWH who switched from standard ART to dolutegravir and lamivudine (DTG + 3TC) in real‐world settings.
Tommy Hing‐cheung Tang   +15 more
wiley   +1 more source

Design and Optimization of Metropolitan Area Networks using Multi-Protocol Label Switching

open access: yesMajlesi Journal of Electrical Engineering
Looking in to the modern technology, we see new inventions and innovations which are unique. As an example, over the past years, new technology has been created in computer networks of which metropolitan area network (MAN) has had a noticeable advance in
Alireza Emamjomeh   +2 more
doaj  

Modular Reinforcement Learning for Multi-Market Portfolio Optimization

open access: yesInformation
Most reinforcement learning (RL) methods for portfolio optimization remain limited to single markets and a single algorithmic paradigm, which restricts their adaptability to regime shifts and heterogeneous conditions.
Firdaous Khemlichi   +2 more
doaj   +1 more source

Fluoride‐Free Mouthwashes Available Over‐The‐Counter in the US‐An Overview

open access: yesInternational Journal of Dental Hygiene, EarlyView.
ABSTRACT Purpose Fluoride‐free mouthwashes (FFM) are commonly used by patients for a variety of cosmetic and/or therapeutic reasons. The purpose of this study was to investigate the composition and purposes of FFM available over‐the‐counter in the US.
Astrid C. Valdivia‐Tapia   +3 more
wiley   +1 more source

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