Results 41 to 50 of about 5,611,148 (333)

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

A Bidirectional Causal Relationship between Headache and IgA Nephropathy: Evidence from a Genetic Study

International Journal of Pain
Background : Pain, a major clinical, social and economic problem, has often been regarded as a symptom that serves as a warning signal of an underlying disease process. And patients with IgA nephropathy (IgAN) frequently present with region-specific pain.
Chengcheng Liu, Qingwen Wang, Xuejia Zheng, Ruiyuan Chen, Liu Xiang, Feng Zhu, Fulin Tao, Junning Zhang, Jingquan He, Yong Dai   +9 more
doaj   +1 more source

EVOLUTIONARY STABLE PROPERTIES OF POLITICAL PARTIES IN INDONESIA [PDF]

, 2004
The major idea is to use memetics as an analytical tool on viewing how the existing political parties towards General Election 2004 creating formation of their presidential candidacy, ideology behind it, the change of political atmosphere it will bring ...
Khanafiah, Mr Deni, Sartika, Mr Tiktik, Situngkir, Mr Hokky   +2 more
core  

Magnetoresistence engineering and singlet/triplet switching in InAs nanowire quantum dots with ferromagnetic sidegates [PDF]

, 2016
We present magnetoresistance (MR) experiments on an InAs nanowire quantum dot device with two ferromagnetic sidegates (FSGs) in a split-gate geometry. The wire segment can be electrically tuned to a single dot or to a double dot regime using the FSGs and
Baumgartner, A., Fábián, G., Madsen, M. H., Makk, P., Nygård, J., Schönenberger, C.   +5 more
core   +2 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Improved treatment of colorectal liver metastases by early response evaluation and regimen adjustment: a prospective study of clinical functional MR-based modeling

Cancer Biology & Medicine
Objective: The aim of the study was to evaluate the feasibility of functional MR in predicting the clinical response to chemotherapy in patients with colorectal liver metastases (CLM).
Wenhua Li, Huan Zhang, Zhe Gong, Yue Li, Zhiyu Chen, Xiaodong Zhu, Mingzhu Huang, Zhe Zhang, Chenchen Wang, Lixin Qiu, Qirong Geng, Jinjia Chang, Xiaoying Zhao, Xuedan Sheng, Wen Zhang, Tong Tong, Weijian Guo   +16 more
doaj   +1 more source

Dynamic contrast-enhanced MR and PET/CT findings of uterine sarcomatoid carcinoma: a case report

BMC Women's Health, 2020
Background Sarcomatoid carcinoma (SC) is a malignant tumour composed of spindle cells. The incidence of SC is low, especially in the uterus. The imaging features of uterine sarcomatoid carcinoma (USC) are rarely reported.
Tingting Cui, Yanfang Jin, Bin Li, Jiyuan Li, Yunlong Yue   +4 more
doaj   +1 more source

Different coloured tears: Dual cultural identity and Tangihanga [PDF]

, 2011
Although whānau/family that are configured by both Pākehā and Māori identities number significantly within New Zealand, there has been little or no attention paid to the ways in which these identities influence the bereavement processes that will ...
Edge, Kiri, Nikora, Linda Waimarie, Rua, Mohi   +2 more
core   +1 more source

Generalized MICZ-Kepler Problems and Unitary Highest Weight Modules [PDF]

, 2007
For each integer $n\ge 1$, we demonstrate that a $(2n+1)$-dimensional generalized MICZ-Kepler problem has an $\mr{Spin}(2, 2n+2)$ dynamical symmetry which extends the manifest $\mr{Spin}(2n+1)$ symmetry. The Hilbert space of bound states is shown to form
Bailey T. N., Georgi H., Guowu Meng, Meng G., Meng G. W., Reed M., Ruibin Zhang, Zelobenko D. P.   +7 more
core   +3 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source