Results 61 to 70 of about 5,322,829 (335)

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation

Molecular Oncology, EarlyView.
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova, Marketa Pavlikova, Lucie Pifkova, Robin Jugas, Tana Machackova, Lenka Radova, Milana Sachlova, Renata Bartosova, Tetiana Samoilenko, Zuzana Feckova, Jana Orlickova, Erika Slamova, Elleni Ponechal Michu, Dagmar Al Tukmachi, Michaela Ruckova, Martina Vodinska, Jan Kotoucek, Tina Catela Ivkovic, Marie Boudna, Lucia Bohovicova, Teodor Stanek, Jana Halamkova, Martin Svoboda, Vladimir Prochazka, Tomas Grolich, Zdenek Kala, Ondrej Slaby   +26 more
wiley   +1 more source

Bipolar-Driven Large Magnetoresistance in Silicon

, 2013
Large linear magnetoresistance (MR) in electron-injected p-type silicon at very low magnetic field is observed experimentally at room temperature. The large linear MR is induced in electron-dominated space-charge transport regime, where the magnetic ...
A. B. Pippard, E. I. Karakushan, Eiji Shikoh, M. A. Lampert, Masashi Shiraishi, Michael P. Delmo, N. W. Ashcroft, R. S. Popovic, S. M. Sze, Teruya Shinjo   +9 more
core   +1 more source

Extended magnetic reconnection across the dayside magnetopause [PDF]

, 2011
The extent of where magnetic reconnection (MR), the dominant process responsible for energy and plasma transport into the magnetosphere, operates across Earth’s dayside magnetopause has previously been only indirectly shown by observations. We report the
Berchem, J., Bogdanova, Y. V., Constantinescu, D., Dunlop, M. W., Eastwood, J., Escoubet, P., Fazakerley, A., Frey, H., Hasegawa, H., Lavraud, B., Liu, Z.-X., Lockwood, Mike, Pu, Z., Shen, C., Shi, J.-K., Sibeck, D., Taylor, M. G. G. T., Volwerk, M., Wang, J., Wild, J. A., Zhang, Q.-H.   +20 more
core   +2 more sources

Two-dimensional Transport Induced Linear Magneto-Resistance in Topological Insulator Bi$_2$Se$_3$ Nanoribbons

, 2011
We report the study of a novel linear magneto-resistance (MR) under perpendicular magnetic fields in Bi2Se3 nanoribbons. Through angular dependence magneto-transport experiments, we show that this linear MR is purely due to two-dimensional (2D) transport,
Abrikosov A. A., Abrikosov A. A., Analytis J. G., Analytis J. G., Butch N. P., Checkelsky J. G., Checkelsky J. G., Chen Y. L., Dong Liang, Eto K., Fan Z., Friedman A. L., Hao Tang, Hasan M. Z., Hsieh D., Hsieh D., Hu J. S., Isihara A., Kong D., Luk’yanchuk I. A., Martin J., McClure J. W., Moore J. E., Morozov S. V., Olsen J. L., Parish M. M., Peng H., Qi X. L., Qu D. X., Richard L. J. Qiu, Steinberg H., Xia Y., Xu R., Xuan P. A. Gao, Zhang H. J., Zhang S. C., Zhang Y., Zhang Y., Zhang Y. B.   +38 more
core   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

The effect of a carbohydrate mouth rinse on performance of the yo-yo intermittent recovery level 1 test with female university level hockey players [PDF]

, 2013
It has been suggested that carbohydrate mouth rinse (CHO-MR) effects short duration, high intensity exercise by activation of sensory receptors on the tongue (Carter et al., 2004: Medicine and Science in Sports and Exercise, 36, 2107–2111).
Middleton, Geoff, Mitchell, Susannah
core  

'How shall we survive': a qualitative study of women's experiences following denial of menstrual regulation (MR) services in Bangladesh. [PDF]

, 2016
BackgroundAbout one quarter of women in Bangladesh are denied menstrual regulation (MR) due to advanced gestation [J Fam Plann Reprod Health Care 41(3):161-163, 2015, Issues Brief (Alan Guttmacher Inst) (3):1-8, 2012].
Biswas, Kamal Kanti, Foster, Diana Greene, Gerdts, Caitlin, Hossain, Altaf, Moseson, Heidi, Raifman, Sarah   +5 more
core   +2 more sources

MR. COOPER AND MR. FAGAN. [PDF]

The Lancet
n ...
openaire   +3 more sources

Failure and Stress Analysis of Glass Fiber Reinforced Laminated Composite Pinned Joints [PDF]

International Journal of Advanced Design and Manufacturing Technology, 2013
In this study, behavior of pin-loaded glass fiber reinforced with polyethylene laminated composites with different stacking sequence and different dimensions has been observed experimentally and stress analysis was performed using ANSYS software. The aim
Suresh Babu Valeru, Tarasasanka Cherukuri   +1 more
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