Results 1 to 10 of about 18,545 (300)

Nonsteroidal Versus Steroidal Mineralocorticoid Receptor Antagonists in Heart Failure: Real‐World Evidence From a Multicenter Cohort Study [PDF]

open access: yesJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Mineralocorticoid receptor antagonists (MRAs) reduce mortality and hospitalization in patients with heart failure (HF). Finerenone, a selective nonsteroidal MRA, has recently demonstrated clinical benefits in patients with HF.
Jheng‐Yan Wu   +2 more
doaj   +2 more sources

Structure of SHOC2-KRAS-PP1C complex reveals RAS isoform-specific determinants and insights into targeting complex assembly by RAS inhibitors [PDF]

open access: yesNature Communications
RAF activation is essential for MAPK signaling and is mediated by RAS binding and the dephosphorylation of a conserved phosphoserine by the SHOC2–RAS–PP1C complex.
Daniel A. Bonsor   +11 more
doaj   +2 more sources

Sensorless Direct Field-Oriented Control of Induction Motor Drive Using Artificial Neural Network-Based Reactive Power MRAS [PDF]

open access: yesSensors
In this paper, advanced sensorless control methods of an induction machine (IM) with the use of a model reference adaptive system (MRAS) estimator are presented, specifically an MRAS using reactive power (Q-MRAS) with an implemented feedforward ...
Marek Kubatko   +6 more
doaj   +2 more sources

An SMC-MRAS Speed Estimator for Sensor-Less Control of DFIG Systems in Wind Turbine Applications

open access: yesEnergies, 2023
A sliding mode control-based model reference adaptive system (SMC-MRAS) estimator for sensor-less control of doubly fed induction generator (DFIG) systems in wind turbine applications is proposed in this paper.
Mwana Wa Kalaga Mbukani   +2 more
doaj   +1 more source

MRAS based speed sensorless control of PMSM Drive for urban electric vehicle [PDF]

open access: yesRevista Română de Informatică și Automatică, 2023
This paper gives a clear visual appearance of the speed predictive control by a Model Reference Adaptive System (MRAS) observer for a Permanent-Magnet Synchronous Motor which is the heart of the electric vehicle’s powertrain, The proposed approach used ...
Bachir BENDJEDIA, Saad CHOUIREB
doaj   +1 more source

Cost Effectiveness of Sodium-Glucose Cotransporter 2 Inhibitors Compared with Mineralocorticoid Receptor Antagonists among Patients with Heart Failure and a Reduced Ejection Fraction

open access: yesCardiovascular Innovations and Applications, 2023
Objective: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are approved for heart failure with reduced ejection fraction (HFrEF). However, their cost-effectiveness remains unknown.
Jingchaun Guo   +5 more
doaj   +1 more source

Modified Super-Twisting Algorithm-Based Model Reference Adaptive Observer for Sensorless Control of the Interior Permanent-Magnet Synchronous Motor in Electric Vehicles

open access: yesMachines, 2023
In this paper, the model reference adaptive system (MRAS) method has been employed to observe speed in sensorless field-oriented control (FOC) with flux weakening (FW) and maximum torque per ampere (MTPA) operations for the interior permanent-magnet ...
Aykut Bıçak, Ayetül Gelen
doaj   +1 more source

Mineralocorticoid receptor antagonists for chronic heart failure: a meta-analysis focusing on the number needed to treat

open access: yesFrontiers in Cardiovascular Medicine, 2023
AimsRecent studies have shown that mineralocorticoid receptor antagonists (MRAs) can decrease mortality in patients with heart failure; however, the application of MRAs in current clinical practice is limited because of adverse effects such as ...
Chang Geng   +6 more
doaj   +1 more source

Non-steroidal Mineralocorticoid Receptor Antagonist Eliciting Cardiorenal Protection is a New Option for Patients with Chronic Kidney Disease

open access: yesKidney Diseases, 2022
Background: Mineralocorticoid receptor antagonists (MRAs) protect cardiorenal function by robust anti-inflammatory and antifibrotic functions beyond classical functions of maintaining fluid and electrolyte homeostasis.
Wenyu Liu, Shengqiang Yu
doaj   +1 more source

Rational drug therapy of chronic heart failure: the role of mineralocorticoid receptor antagonists: review

open access: yesConsilium Medicum, 2022
Mineralocorticoid receptor antagonists (MRAs) are part of basic medical therapy for heart failure. The clinical efficacy of MRAs has been proven by randomized clinical trials. To review comparative efficacy and tolerability data between the two main MRAs,
Natalia V. Safronova   +2 more
doaj   +1 more source

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