Results 131 to 140 of about 839,337 (241)

Impaired Generation of High‐Affinity Memory B Cells and Neutralizing Antibodies Against SARS‐CoV‐2 in Adolescents and Young Adults With Juvenile Idiopathic Arthritis Treated With Tumor Necrosis Factor Inhibitors

ACR Open Rheumatology, Volume 8, Issue 1, January 2026.
Objective We evaluated the immunogenicity of SARS‐CoV‐2 mRNA vaccines in patients with juvenile idiopathic arthritis (JIA), focusing on the generation of spike‐specific memory B cells (MBCs) and of neutralizing antibodies, and assessed the impact of disease‐modifying antirheumatic drugs, particularly tumor necrosis factor inhibitors (TNFi).
Angela Aquilani, Francesca Marinaro, Giusyda Tarantino, Ivan Caiello, Lorenzo Nobili, Eva Piano Mortari, Rebecca Nicolai, Maria Isabella Petrone, Concetta Castilletti, Silvia Magni‐Manzoni, Fabrizio De Benedetti, Rita Carsetti, Emiliano Marasco   +12 more
wiley   +1 more source

Comparative mRNA booster effectiveness against death or hospitalization with COVID-19 pneumonia across at-risk US Veteran populations

Nature Communications, 2023
Studies of comparative mRNA booster effectiveness among high-risk populations can inform mRNA booster-specific guidelines. The study emulated a target trial of COVID-19 vaccinated U.S.
J. Daniel Kelly, Samuel Leonard, W. John Boscardin, Katherine J. Hoggatt, Emily N. Lum, Charles C. Austin, Amy Byers, Phyllis C. Tien, Peter C. Austin, Dawn M. Bravata, Salomeh Keyhani   +10 more
doaj   +1 more source

Polyphenol‐Mediated Engineering of Lipid Nanoparticles With Crystalline Mesophases

Advanced Materials, Volume 38, Issue 6, 27 January 2026.
A polyphenol‐mediated strategy enables the one‐step formation of lipid nanoparticles with nonlamellar mesophases, including micellar cubic and hexagonal structures. These highly ordered nanostructures accommodate a wide range of cargos—from metal ions to mRNA—and offer a modular and versatile platform for constructing functional lipid‐based delivery ...
Shiyao Li, Patrick Charchar, Haitao Yu, Zhixing Lin, Hamish G. Brown, Wanjun Xu, Chan‐Jin Kim, Irene Yarovsky, Yi Ju, Frank Caruso   +9 more
wiley   +1 more source

Unique Aerofoil‐Structured Microfluidics for High Throughput Lipid Nanoparticle Formulation Screening and Scale‐up

Advanced Science, Volume 13, Issue 6, 30 January 2026.
This study presents aerofoiled microfluidic structures optimized for efficient mixing and lipid nanoparticle (LNP) formation across broad flow rates. Based on this design, two dedicated systems are introduced: MiNANO‐form for high‐throughput formulation screening and MiNANO‐scale for continuous large‐scale production, enabling reproducible, high ...
Dongsheng Liu, Mingzhi Yu, Yuguo Zhang, Allen Mathew, Tianyu Guan, Liang Yao, Xianqing Wang, Wenxin Wang, Nan Zhang   +8 more
wiley   +1 more source

Replacing Helper Lipids With Cationic Lipids Enhances mRNA Lipid Nanoparticles Stability in Solution

Advanced Science, Volume 13, Issue 3, 14 January 2026.
Partial Replacement of phospholipid lipid by cationic lipid improves storage stability of commercial mRNA LNPs by stabilizing their internal microstructure. Abstract Messenger RNA lipid nanoparticles (mRNA‐LNPs) have achieved remarkable success in clinical vaccination efforts to curb the COVID‐19 pandemic, and have attracted tremendous interest from ...
Rui Chen, Letao Xu, Nan Zhang, Haitao Yu, Xing Wang, Jiali Zhai, Fiona Whelan, Phillip Elliott, Chun‐Xia Zhao   +8 more
wiley   +1 more source

Multimodality imaging and histopathology in a young man presenting with fulminant lymphocytic myocarditis and cardiogenic shock after mRNA-1273 vaccination [PDF]

, 2021
Mazhar Kadwalwala, Bhawneet Chadha, Jamel Ortoleva, Maurice F. Joyce   +3 more
openalex   +1 more source

The 5′ Cap Epitranscriptome and Beyond: Natural and Engineered 5′ Cap Modifications for Optimizing mRNA Therapeutics and Functional Studies

ChemMedChem, Volume 21, Issue 2, January 2026.
5′ Cap modifications can be introduced via enzymes or chemical synthesis. Natural and non‐natural 5′ cap structures affect mRNA properties, including translation (T), stability (S), and/or immunogenicity (I). Eukaryotic mRNAs made by in vitro transcription have emerged as medical modalities for vaccination and protein replacement therapy. The 5′ cap is
Greta Charlotte Dahm, Melissa Pieper, Helena Schepers, Andrea Rentmeister   +3 more
wiley   +1 more source

SARS‐CoV‐2 mRNA Vaccination Leads to Transient Humoral and B Cell Bystander Responses in Adults

European Journal of Immunology, Volume 56, Issue 1, January 2026.
SARS‐CoV‐2 mRNA vaccination triggers bystander activation of B cells, transiently increasing antibody levels after the first vaccination against influenza, RSV, and tetanus. Reactivation of B cell responses also occurred, where (CD11c+) MBC and DN3 are expanded after SARS‐CoV‐2 mRNA vaccination, independent of antigen exposure.
Lisan H. Kuijper, Laura Y. L. Kummer, Laura Fernandez Blanco, Karlijn van der Straten, Mathieu A. F. Claireaux, Amélie V. Bos, Miranda C. Dieker‐Meijer, Tineke Jorritsma, Mariël C. Duurland, Maurice Steenhuis, Juan J. Garcia Vallejo, Koos P. J. van Dam, Eileen W. Stalman, Luuk Wieske, Sander W. Tas, Laura Boekel, Gert‐Jan Wolbink, Theo Rispens, Taco W. Kuijpers, Filip Eftimov, Marit J. van Gils, Anja ten Brinke, S. Marieke van Ham, T2B! immunity against SARS‐CoV‐2 study group   +23 more
wiley   +1 more source

Moderna (mRNA-1273) Covid-19 Vaccine, “A Systematic Review” [PDF]

, 2021
A Global pandemic, declared by WHO, caused due to a deadly virus known as a “SARS-Cov-2”, has resulted in 4.3 million deaths. Its RNA based genome and lack of proofreading ability has made this virus more prone to get the frequent mutations and results ...
Abid, Sidra, Imam, Meisha, Rehan, Hafiz Muhammad, Zahid, Rohama   +3 more
core   +1 more source

CRK2 modulates flowering in Arabidopsis together with GLYCINE‐RICH RNA‐BINDING PROTEIN 7

New Phytologist, EarlyView.
Francisco J. Colina, Julia Krasensky‐Wrzaczek, Alegría Pérez‐Guillén, Michael Wrzaczek   +3 more
wiley   +1 more source