Results 101 to 110 of about 19,056,956 (378)
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
An essential nuclear protein in trypanosomes is a component of mRNA transcription/export pathway. [PDF]
PLoS ONE, 2011 In eukaryotic cells, different RNA species are exported from the nucleus via specialized pathways. The mRNA export machinery is highly integrated with mRNA processing, and includes a different set of nuclear transport adaptors as well as other mRNA ...
Mariana Serpeloni +12 more
doaj +1 more source
mRNA cap regulation in mammalian cell function and fate [PDF]
, 2019 In this review we explore the regulation of mRNA cap formation and its impact on mammalian cells. The mRNA cap is a highly methylated modification of the 5’ end of RNA pol II-transcribed RNA.
Cowling, Victoria, Galloway, Alison
core +2 more sources
Defective minor spliceosome mRNA processing results in isolated familial growth hormone deficiency
EMBO Molecular Medicine, 2014 The molecular basis of a significant number of cases of isolated growth hormone deficiency remains unknown. We describe three sisters affected with severe isolated growth hormone deficiency and pituitary hypoplasia caused by biallelic mutations in the ...
J. Argente +9 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
MicrobiologyOpen, 2019 RNase Y is a major endoribonuclease in Group A streptococcus (GAS) and other Gram‐positive bacteria. Our previous study showed that RNase Y was involved in mRNA degradation and processing in GAS.
Zhiyun Chen +4 more
doaj +1 more source
Virulence- and signaling-associated genes display a preference for long 3′UTRs during rice infection and metabolic stress in the rice blast fungus [PDF]
, 2019 Generation of mRNA isoforms by alternative polyadenylation (APA) and their involvement in regulation of fungal cellular processes, including virulence, remains elusive.
Demuez, Marie +5 more
core +1 more source
Differential mRNA Processing in Hematopoietic Stem Cells
Stem Cells, 2005 Abstract Hematopoietic stem cells (HSCs) maintain tissue homeostasis by rapidly responding to environmental changes. Although this function is well understood, the molecular mechanisms governing this characteristic are largely unknown. We used a sequenced-based strategy to explore the role of both transcriptional and post-transcriptional
Teresa V, Bowman +17 more
openaire +2 more sources
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Gain-of-function reporters for analysis of mRNA 3′-end formation: Design and optimization
BioTechniques, 2016 The concept of mRNA 3′-end formation as a static, minimally regulated housekeeping process has undergone a paradigm shift. Many recent studies have shown that accurate and efficient 3′-end formation of mRNA is highly regulated and that dysregulation of ...
Natoya Peart, Eric J Wagner
doaj +1 more source