Results 321 to 330 of about 19,056,956 (378)

An Ultrafast Self‐Gelling Versatile Hydrogel for Rapid Infected Burn Wound Repair in Military Medicine

Advanced Functional Materials, EarlyView.
A self‐gelling PG@PAC (POD/Gel‐CDH@PA/CHX) powder is developed for infected burn care in austere settings. Upon contact with wound exudate, it instantly forms an adhesive hydrogel, providing simultaneous hemostasis, broad‐spectrum antibacterial activity, reactive oxygen species scavenging, and immunomodulation. In a murine model of S.
Liping Zhang, Zhangrui Wu, Xiansheng Zhao, Geng Wang, Quyang Yang, Minxia zhang, Xiaowei Wang, Xiujun Cheng, Changyue Wu, Dan Wu, Yutian Yang, Canbin Dong, Tao Zhang, Weiqiang Tan, Ningwen Zhu   +14 more
wiley   +1 more source

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, EarlyView.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

MagPiezo: A Magnetogenetic Platform for Remote Activation of Endogenous Piezo1 Channels in Endothelial Cells

Advanced Functional Materials, EarlyView.
MagPiezo enables wireless activation of endogenous Piezo1 channels without genetic modification using 19 nm magnetic nanoparticles and low‐intensity magnetic fields. It generates torque forces at the piconewton scale to trigger mechanotransduction in endothelial cells, standing as a novel platform to interrogate and manipulate Piezo1 activity in vitro.
Susel Del Sol‐Fernández, Mariarosaria De Simone, Yilian Fernández‐Afonso, Daniel Garcia‐Gonzalez, Pablo Martínez‐Vicente, Thomas van Zanten, Raluca M. Fratila, Maria Moros   +7 more
wiley   +1 more source

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mRNA Processing

Methods in Molecular Biology, 2017
Yongsheng Shi
semanticscholar   +2 more sources

Targeting mRNA processing as an anticancer strategy

Nature Reviews Drug Discovery, 2019
Discoveries in the past decade have highlighted the potential of mRNA as a therapeutic target for cancer. Specifically, RNA sequencing revealed that, in addition to gene mutations, alterations in mRNA can contribute to the initiation and progression of cancer.
J. Desterro, Pedro Bak-Gordon, M. Carmo-Fonseca   +2 more
semanticscholar   +4 more sources

Metal-captured inhibition of pre-mRNA processing activity by CPSF3 controls Cryptosporidium infection

Science Translational Medicine, 2019
Targeting parasitic endonuclease CPSF3 with an oxaborole offers a potent and selective candidate treatment against cryptosporidiosis. Controlling Cryptosporidium The apicomplexan parasite Cryptosporidium causes potentially life-threatening ...
C. Swale, Alexandre Bougdour, Audrey Gnahoui-David, Julie Tottey, S. Georgeault, F. Laurent, A. Palencia, Mohamed-Ali Hakimi   +7 more
semanticscholar   +1 more source

mRNA processing in the Trypanosomatidae

Experientia, 1991
Members of the Trypanosomatidae, which include the African trypanosomes, the American trypanosomes and the leishmanias, cause disease in vast proportions in man and his livestock and are a major detrimental factor to the social and economic well-being of the third world.
K, Perry, N, Agabian
openaire   +2 more sources

mRNA processing in Antonospora locustae spores

Molecular Genetics and Genomics, 2008
Microsporidia are a group of intracellular parasites characterized by highly reduced and compact genomes. The presence of a high gene density had several consequences for microsporidian genomes, including a high frequency of overlap between transcripts of adjacent genes. This phenomenon is apparently widespread in microsporidia, and strongly correlated
Nicolas, Corradi, Lena, Burri, Patrick J, Keeling   +2 more
openaire   +2 more sources

Pre-mRNA processing and mRNA nuclear export

Current Opinion in Cell Biology, 1989
The primary transcript of a prokaryotic gene is translated immediately following or during synthesis, whereas in eukaryotes, messenger RNA (mRNA) precursors (premRNAs) are synthesized in the nucleus and are then structurally altered and relocated to the cytoplasm before translation (Fig. 1).
openaire   +2 more sources

Eukaryotic mRNA Processing

1997
Abstract This volume focuses on the major aspects of post-transcriptional mRNA processing in the nucleus of eukaryotic cells. Each of the described mRNA reactions is required for proper gene expression and can also serve as a control point for regulating the expression of many genes, for example during embryonic development or in ...
openaire   +1 more source