Results 221 to 230 of about 199,785 (356)

HTERT mRNA/Survivin Peptide-double-loaded Autologous Dendritic Cell Vaccine [PDF]

, 2020
National Cancer Institute
openalex   +1 more source

Machine Learning‐Enhanced Random Matrix Theory Design for Human Immunodeficiency Virus Vaccine Development

Advanced Intelligent Discovery, EarlyView.
This study integrates random matrix theory (RMT) and principal component analysis (PCA) to improve the identification of correlated regions in HIV protein sequences for vaccine design. PCA validation enhances the reliability of RMT‐derived correlations, particularly in small‐sample, high‐dimensional datasets, enabling more accurate detection of ...
Mariyam Siddiqah, Muhammad Zulqarnain Zeb, Muhammad Husnain Zeb, Babar Shabbir   +3 more
wiley   +1 more source

Tomatine as a versatile adjuvant boosts mRNA vaccine responses. [PDF]

Mater Today Bio
Xiao W, Qin S, Li X, Jin X, Zhu A, He X, Duan X, Chen Y, Zhang Y, Fan N, Zheng Q, Li G, He Z, Chen K, Huang H, Wei X, Moog C, Su B, Song X.   +18 more
europepmc   +1 more source

A comparative study of the COVID-19 vaccine efficacy among cancer patients: mRNA versus non-mRNA

, 2023
Andhika Rachman, Anggraini Iriani, Lugyanti Sukrisman, Wulyo Rajabto, Nadia Ayu Mulansari, Anna Mira Lubis, Rahmat Cahyanur, Findy Prasetyawati, Dimas Priantono, Bayu Bijaksana Rumondor, Rachelle Betsy, Samuel Juanputra   +11 more
openalex   +2 more sources

Toward Predictable Nanomedicine: Current Forecasting Frameworks for Nanoparticle–Biology Interactions

Advanced Intelligent Discovery, EarlyView.
Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova, Michael Nicholls, Nicola Russo, Gueorgui Mihaylov, Konstantin Nikolic   +4 more
wiley   +1 more source

Influenza mRNA vaccine reduces pathogenicity and transmission of A(H5N1) virus in a ferret model. [PDF]

NPJ Vaccines
Hatta M, Brock N, Hauguel T, Feng C, Huang Y, Ritter JM, Hatta Y, Keller MW, De Souza I, Hossain J, Pusch EA, Rowe T, Zhang H, Cui L, O'Leary S, De La Cruz JA, Johnson MC, Belser JA, Sun X, Liddell J, Creech M, Rouse JR, Carney P, Chang J, Currier M, Wang L, Kirby MK, Di H, Barnes JR, Stevens J, Dugan VG, Davis CT, Wentworth DE, Allen PS, Maines TR, Zhou B.   +35 more
europepmc   +1 more source

Engineering Tertiary Lymphoid Structures: Nanomedicine, Bioengineering, and Biomaterials for Precision Immunotherapy

Advanced NanoBiomed Research, EarlyView.
This review explains how biomaterials and nanoparticles can be used to induce or modulate tertiary lymphoid structures (TLSs), which are ectopic immune hubs that form in nonlymphoid tissues during chronic disease and cancer. By comparing different methods, the article highlights design principles for modeling TLSs or recapitulating specific TLS ...
Shaza Karaman, Mei ElGindi, Jeremy Teo
wiley   +1 more source

Mannose‐Modified Cationic Liposome‐Based mRNA Therapeutics for Improved Triple‐Negative Breast Cancer Immunotherapy

Advanced NanoBiomed Research, EarlyView.
Schematic illustration of mTEM8‐loaded cationic liposome (cLipo‐Man/mTEM8) therapeutics for improved triple‐negative breast cancer immunotherapy. Despite triple‐negative breast cancer (TNBC) is the most heterogeneous and aggressive subtype of breast cancer, immunotherapy is emerging as a promising therapy.
Kexin Deng, Juping Sun, Junyu Liu, Yuqi Zhang, Wanwan Liu, Xiaobin Li, Han Wu, Juan Li, Jisong Zhang, Chanyuan Jin, Can Yang Zhang   +10 more
wiley   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source