Results 271 to 280 of about 199,785 (356)

EP9158H: An Immunoinformatics-Designed mRNA Vaccine Encoding Multi-Epitope Antigens and Dual TLR Agonists for Tuberculosis Prevention. [PDF]

Bioengineering (Basel)
Zhang M, Ali SL, Tian Y, Abduldayeva A, Zhou S, An Y, Li Y, Ni R, Zhang L, Liu Y, Sun W, Gong W.   +11 more
europepmc   +1 more source

Selection, Design,and Immunogenicity Studies of ASFVAntigens for Subunit mRNA Cocktail Vaccines with Specific Immune ResponseProfiles

Fangfeng Yuan (21499884), Junru Cui (6281480), Tianlei Wang (17064968), Jane Qin (14829994), Ju Hyeong Jeon (14829997), Huiming Ding (196523), Charles A. Whittaker (8124875), Renhuan Xu (14830006), Hong Cao (122228), Jianzhu Chen (183751)   +9 more
openalex   +1 more source

Polyglycerol‐Based Lipids: A Next‐Generation Alternative to PEG in Lipid Nanoparticles for Advanced Drug Delivery Systems

Macromolecular Rapid Communications, EarlyView.
Linear polyglycerol is proposed as a PEG‐alternative in mRNA‐loaded lipid nanoparticles to limit activation of anti‐PEG antibodies and reduce immunogenicity. Resulting nanoparticles may provide similar gene delivery capabilities, while preventing binding of anti‐PEG antibodies compared to PEGylated counterparts.
Yara Ensminger, Rashmi Rashmi, Michael Karimov, Gideon Nölte, Markus Hafke, Ann‐Cathrin Schmitt, David Díaz‐Oviedo, Johannes Köbberling, Rainer Haag   +8 more
wiley   +1 more source

mRNA Vaccine Development in the Fight Against Zoonotic Viral Diseases. [PDF]

Viruses
Tan BEK, Tham SK, Poh CL.
europepmc   +1 more source

Data Sheet 1_Design and immunogenicity of a quadrivalent mRNA vaccine targeting HSV-2 with comparative evaluation of co-formulated and admixed formulations.docx

Youngran Cho (16532495), Chanwoo Lee (2006302), Sang-In Park (2849120), Yeongjun Kim (11218908), Yu-Sun Lee (7379705), Seonghyun Lee (13943517), Subin Yoon (3863965), Gahyun Roh (19832295), Dahyeon Ha (21517223), Ayoung Oh (21517220), Kyusang Cho (22786634), Jisun Lee (308634), Hyo-Jung Park (11476168), Hye-Ra Lee (245463), Jae-Hwan Nam (670465)   +14 more
openalex   +1 more source

Who Will Protect the Children?

Annals of the Child Neurology Society, EarlyView.
William D. Graf, Leon G. Epstein
wiley   +1 more source

Poly(sarcosine) Lipid Synthesis From CO2‐Based Sarcosine‐N‐Carboxyanhydride

Macromolecular Rapid Communications, EarlyView.
In this work, we optimize and scale‐up a CO2‐based synthesis of sarcosine‐N‐carboxyanhydride (Sar‐NCA) to the gram scale. The low toxicity and simplicity of the approach make it an attractive alternative to current toxic phosgene‐based approaches. The CO2‐based Sar‐NCA has sufficient purity for controlled polymerization.
Florian T. Kaps, Leon Quellmalz, Annika D. S. Richardson, Anna‐Lena Ziegler, Sarah Moreau, Susanne K. Wiedmer, Timo Repo, Robert Luxenhofer   +7 more
wiley   +1 more source

A single-dose mRNA vaccine protects mice from lethal Crimean-Congo hemorrhagic fever virus infection. [PDF]

NPJ Vaccines
Rao J, Li J, Jiang T, Guo W, Zhang X, Zhang Z, Su J, Lu M, Hu X, Liu X, Qu R, Zhu T, Hu C, Liu K, Wang H, Shan C.   +15 more
europepmc   +1 more source

Machine Learning for Predictive Modeling in Nanomedicine‐Based Cancer Drug Delivery

Med Research, EarlyView.
The integration of AI/ML into nanomedicine offers a transformative approach to therapeutic design and optimization. Unlike conventional empirical methods, AI/ML models (such as classification, regression, and neural networks) enable the analysis of complex clinical and formulation datasets to predict optimal nanoparticle characteristics and therapeutic
Rohan Chand Sahu, Sanchit Arora, Dinesh Kumar, Ashish Kumar Agrawal   +3 more
wiley   +1 more source

Design and immunogenicity of a quadrivalent mRNA vaccine targeting HSV-2 with comparative evaluation of co-formulated and admixed formulations. [PDF]

Front Immunol
Cho Y, Lee C, Park SI, Kim Y, Lee YS, Lee S, Yoon S, Roh G, Ha D, Oh A, Cho K, Lee J, Park HJ, Lee HR, Nam JH.   +14 more
europepmc   +1 more source