Results 291 to 300 of about 199,785 (356)

Advances in Elemene Nanodelivery Systems: From Material Design to Disease Treatment

Rare Metals, EarlyView.
ABSTRACT Elemene (ELE) is a bioactive sesquiterpenoid extracted from traditional Chinese herbs, demonstrating broad‐spectrum antitumor, anti‐inflammatory, and analgesic properties with significant therapeutic potential. However, its clinical utility is constrained by inherent physicochemical limitations, including volatility and hydrophobicity, which ...
Xiao Wang, Jiatong Lin, Yi Peng, Zehua Wu, Yingying Liu, Wei Duan, Qiaolin Wei, Jia‐Wei Shen, Jiang‐Xing Chen, Yong Guo   +9 more
wiley   +1 more source

SARS-CoV-2 mRNA Vaccine Effectiveness in the Borriana COVID-19 Cohort: A Prospective Population-Based Cohort Study. [PDF]

Epidemiologia (Basel)
Domènech-Montoliu S, Pérez-Olaso Ó, Sala-Trull D, Del Rio-Gonzalez A, López-Diago L, Aleixandre-Gorriz I, Pac-Sa MR, Sánchez-Urbano M, Satorres-Martinez P, Notari-Rodriguez C, Casanova-Suárez J, Ruiz-Puig R, Badenes-Marques G, Aparisi-Esteve L, Domènech-León C, Romeu-Garcia MA, Arnedo-Pena A.   +16 more
europepmc   +1 more source

Balancing allocative and dynamic efficiency with redundant R&D allocation: The role of organizational proximity and centralization

Strategic Management Journal, EarlyView.
Abstract Research Summary Resource‐based‐view scholars have mainly examined two resource allocation approaches for competitive advantage in multiunit firms: resource sharing and resource redeployment. These approaches emphasize allocative efficiency—the optimal allocation of resources to maximize their current value. In technology‐intensive industries,
Vivek Tandon, Anand Nandkumar, Ronak Mogra, Kannan Srikanth   +3 more
wiley   +1 more source

The credibility struggle of mRNA vaccine rumors: A communication model to understand the impact of skepticism on public perception. [PDF]

J Public Health Res
Hammarlin MM, Miegel F, Kokkinakis D, Stoencheva J.   +3 more
europepmc   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Development and characterization of a bivalent mRNA vaccine targeting the Delta and Omicron variants of SARS-CoV-2. [PDF]

Hum Vaccin Immunother
Xiong XC, Zhang NN, Wu M, Cao TS, Deng K, Wang ZX, Deng YQ, Qin CF, Ye Q.   +8 more
europepmc   +1 more source

Nasal Delivery of mRNA Using Thermoresponsive Gellable Aqueous Biphasic Systems

Small, EarlyView.
Nasal delivery of mRNA using gellable aqueous biphasic systems (ABS) represents a noninvasive alternative while reducing the need for trained professionals and cold chain storage. Composed of gelatin, PEG, and water, these thermoresponsive hydrogels ensure controlled mRNA delivery and prolonged retention at the nasal mucosa, improving transfection ...
Bojan Kopilovic, Nabila Laroui, João A.P. Coutinho, Chantal Pichon, Mara G. Freire   +4 more
wiley   +1 more source

Polyvalent mRNA vaccine targeting outer surface protein C affords multi-strain protection against Lyme disease. [PDF]

NPJ Vaccines
Pfeifle A, Lansdell C, Zhang W, Tamming LA, Anderson-Duvall R, Thulasi Raman SN, Gravel C, Wu J, Frahm G, Creskey M, Voordouw MJ, Coatsworth H, Qiu W, Marconi RT, Sauve S, Wang L, Zhang X, Johnston MJW, Li X.   +18 more
europepmc   +1 more source

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

Small, EarlyView.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti, Marius F.W. Trollmann, Christina Wichmann, Thomas Gutsmann, Christian Eggeling, Rainer A. Böckmann   +5 more
wiley   +1 more source

A novel multi-epitope mRNA vaccine against colorectal cancer: in silico design and immune efficacy profiling. [PDF]

Front Immunol
Wang L, Zhou X, Wei Y, Lin J.
europepmc   +1 more source