Results 321 to 330 of about 199,785 (356)

The Quest for mRNA Vaccines

Nucleic Acid Therapeutics, 2022
The success of mRNA vaccines against COVID-19 is nothing short of a medical revolution. Given its chemical lability the use of mRNA as a therapeutic has been counterintuitive and met with skepticism. The development of mRNA-based COVID-19 vaccines was the culmination of long and painstaking efforts by many investigators spanning over 30 years and ...
Eli, Gilboa, David, Boczkowski, Smita K, Nair   +2 more
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Adjuvant-Enhanced mRNA Vaccines

2016
Recent advances in molecular biology have led to dramatic enhancement of the stability of in vitro transcribed (IVT) messenger RNA (mRNA) and improvement in its translational efficacy. Nowadays, mRNA-based vaccines represent a promising approach in the field of anticancer immunotherapy, gaining attention over the earlier-established bacteria-, virus ...
Bialkowski, Lukasz, Van Der Jeught, Kevin, Renmans, Dries, van Weijnen, Alexia, Heirman, Carlo, Keyaerts, Marleen, Breckpot, Karine, Thielemans, Kris   +7 more
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Self-Amplifying mRNA Vaccines

2015
This chapter provides a brief introduction to nucleic acid-based vaccines and recent research in developing self-amplifying mRNA vaccines. These vaccines promise the flexibility of plasmid DNA vaccines with enhanced immunogenicity and safety. The key to realizing the full potential of these vaccines is efficient delivery of nucleic acid to the ...
Luis A, Brito, Sushma, Kommareddy, Domenico, Maione, Yasushi, Uematsu, Cinzia, Giovani, Francesco, Berlanda Scorza, Gillis R, Otten, Dong, Yu, Christian W, Mandl, Peter W, Mason, Philip R, Dormitzer, Jeffrey B, Ulmer, Andrew J, Geall   +12 more
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Prophylactic mRNA vaccination against allergy

Current Opinion in Allergy & Clinical Immunology, 2010
mRNA vaccines have recently been re-discovered as an attractive alternative to the more prominent DNA vaccines, as they harbor many advantages with respect to safety and regulatory issues. Whereas most mRNA vaccines are focused on tumor therapy, this type of vaccine has now also been successfully employed for prophylactic immunization against type I ...
Richard, Weiss, Sandra, Scheiblhofer, Elisabeth, Roesler, Fatima, Ferreira, Josef, Thalhamer   +4 more
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An mRNA vaccine for influenza

Nature Biotechnology, 2012
An influenza vaccine made of stabilized mRNA may allow vaccine design and manufacture to keep pace with viral evolution.
Sook-San, Wong, Richard J, Webby
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Respiratory Syncytial Virus Vaccine (mRNA)

Hospital Pharmacy
Each month, subscribers to The Formulary Monograph Service receive 5 to 6 well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to Pharmacy and Therapeutics Committees. Subscribers also receive monthly 1-page summary monographs on agents that are useful for agendas and pharmacy/nursing ...
Terri L. Levien, Danial E. Baker
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mRNA Vaccine Slows Melanoma Recurrence

Cancer Discovery, 2023
Abstract Findings from the phase IIb KEYNOTE-942 trial indicate that the investigational vaccine mRNA-4157/V940 plus pembrolizumab is a potential adjuvant therapy for high-risk melanoma. Following surgery, patients who received the combination experienced a significant reduction in disease recurrence risk, compared with those given just ...
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Recent innovations in mRNA vaccines

Current Opinion in Immunology, 2016
Nucleic acid-based vaccines are being developed as a means to combine the positive attributes of both live-attenuated and subunit vaccines. Viral vectors and plasmid DNA vaccines have been extensively evaluated in human clinical trials and have been shown to be safe and immunogenic, although none have yet been licensed for human use.
Jeffrey B Ulmer, Andrew J Geall
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Computational design of mRNA vaccines

Vaccine
mRNA technology has emerged as a successful vaccine platform that offered a swift response to the COVID-19 pandemic. Accumulating evidence shows that vaccine efficacy, thermostability, and other important properties, are largely impacted by intrinsic properties of the mRNA molecule, such as RNA sequence and structure, both of which can be optimized ...
Yoo-Ah, Kim, Kambiz, Mousavi, Amirali, Yazdi, Magda, Zwierzyna, Marco, Cardinali, Dillion, Fox, Thomas, Peel, Jeff, Coller, Kunal, Aggarwal, Giulietta, Maruggi   +9 more
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Vaccination with Messenger RNA (mRNA)

2008
Both DNA and mRNA can be used as vehicles for gene therapy. Because the immune system is naturally activated by foreign nucleic acids thanks to the presence of Toll-like Receptors (TLR) in endosomes (TLR3, 7, and 8 detect exogenous RNA, while TLR9 can detect exogenous DNA), the delivery of foreign nucleic acids usually induces an immune response ...
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